TY - JOUR
T1 - Medicinal plants as protective strategies against parkinson’s disease
AU - Mazo, Natalia Areiza
AU - Echeverria, Valentina
AU - Cabezas, Ricardo
AU - Ávila-Rodriguez, Marco
AU - Tarasov, Vadim V.
AU - Yarla, Nagendra S.
AU - Aliev, Gjumrakch
AU - Barreto, George E.
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Parkinson’s disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-kB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.
AB - Parkinson’s disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-kB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.
KW - Dopaminergic neurons
KW - Neuroprotective fruits
KW - Parkinson’s disease
KW - Phytochemicals
KW - Signaling pathways
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=85026505069&partnerID=8YFLogxK
U2 - 10.2174/1381612823666170316142803
DO - 10.2174/1381612823666170316142803
M3 - Review article
C2 - 28302024
AN - SCOPUS:85026505069
SN - 1381-6128
VL - 23
SP - 4180
EP - 4188
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 28
ER -