TY - JOUR
T1 - Mesoscale Clusters in the Crystallisation of Organic Molecules
AU - Barua, Harsh
AU - Svärd, Michael
AU - Rasmuson, Åke C.
AU - Hudson, Sarah P.
AU - Cookman, Jennifer
N1 - Publisher Copyright:
© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
PY - 2024/3/4
Y1 - 2024/3/4
N2 - The early stages of the molecular self-assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X-ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large-molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.
AB - The early stages of the molecular self-assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X-ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large-molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.
KW - Mesoscale Cluster
KW - Nanoscale Characterisation Methods
KW - Nonclassical Nucleation
KW - Organic Compounds
KW - Pre-Nucleation
UR - http://www.scopus.com/inward/record.url?scp=85180190096&partnerID=8YFLogxK
U2 - 10.1002/anie.202312100
DO - 10.1002/anie.202312100
M3 - Short survey
C2 - 38055699
AN - SCOPUS:85180190096
SN - 1433-7851
VL - 63
SP - e202312100
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 10
M1 - e202312100
ER -