Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors

Zaida Díaz-Cabiale, Meritxell Vivó, Alberto Del Arco, William T. O'Connor, Michael K. Harte, Christa E. Müller, Emili Martínez, Patrizia Popoli, Kjell Fuxe, Sergi Ferré

Research output: Contribution to journalArticlepeer-review

Abstract

Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferent neurons. Recent behavioral and biochemical studies suggest the existence of specific interactions between adenosine A2A receptors (A2AR), dopamine D2 receptors (D2R) and the group I metabotropic mGlu5 receptors (mGlu5R) in the dorsal striatum. The dual-probe approach in vivo microdialysis technique in freely moving rats was used to study the role of mGlu5R/A2AR/D2R interactions in the modulation of the ventral striopallidal GABA pathway. Perfusion of a selective mGlu5R agonist (CHPG) in the nucleus accumbens facilitated GABA release in the ipsilateral ventral pallidum. This effect was strongly potentiated by co-perfusion with the A2AR agonist CGS 21680. Co-perfusion with the D2R agonist quinpirole counteracted the increase in pallidal GABA levels induced by CGS 21680 and by CGS 21680 plus CHPG. These results demonstrate that mGlu5R/A2AR/D2R interactions play an important modulatory role in the function of the ventral striopallidal GABA pathway, which might have implications for the treatment of schizophrenia and drug addiction.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalNeuroscience Letters
Volume324
Issue number2
DOIs
Publication statusPublished - 17 May 2002
Externally publishedYes

Keywords

  • Adenosine A receptor
  • Dopamine D receptor
  • Gamma-aminobutyric acid
  • Metabotropic mGlu5 receptor
  • Microdialysis
  • Nucleus accumbens
  • Phencyclidine
  • Ventral pallidum

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