Abstract
Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferent neurons. Recent behavioral and biochemical studies suggest the existence of specific interactions between adenosine A2A receptors (A2AR), dopamine D2 receptors (D2R) and the group I metabotropic mGlu5 receptors (mGlu5R) in the dorsal striatum. The dual-probe approach in vivo microdialysis technique in freely moving rats was used to study the role of mGlu5R/A2AR/D2R interactions in the modulation of the ventral striopallidal GABA pathway. Perfusion of a selective mGlu5R agonist (CHPG) in the nucleus accumbens facilitated GABA release in the ipsilateral ventral pallidum. This effect was strongly potentiated by co-perfusion with the A2AR agonist CGS 21680. Co-perfusion with the D2R agonist quinpirole counteracted the increase in pallidal GABA levels induced by CGS 21680 and by CGS 21680 plus CHPG. These results demonstrate that mGlu5R/A2AR/D2R interactions play an important modulatory role in the function of the ventral striopallidal GABA pathway, which might have implications for the treatment of schizophrenia and drug addiction.
Original language | English |
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Pages (from-to) | 154-158 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 324 |
Issue number | 2 |
DOIs | |
Publication status | Published - 17 May 2002 |
Externally published | Yes |
Keywords
- Adenosine A receptor
- Dopamine D receptor
- Gamma-aminobutyric acid
- Metabotropic mGlu5 receptor
- Microdialysis
- Nucleus accumbens
- Phencyclidine
- Ventral pallidum