Microbiota in pouchitis and de novo crohn’s disease of the ileal pouch

J. Calvin Coffey, Jarlath Bolger

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is the surgical treatment of choice for patients with medically refractory ulcerative colitis or with familial adenomatous polyposis (FAP). Primary idiopathic pouchitis and de novo Crohn’s disease can affect the ileal pouch and cause significant morbidity. Although the cause of both is unknown, abnormalities in the pouch microbiota, coupled with a favorable genetic and immunological context, are thought to play a major pathobiological role in each. The aim of this chapter is to review the literature on the microbiota of the ileal pouch, concentrating on how disturbances of microbiota relate to pouchitis and Crohn’s disease of the pouch.

Original languageEnglish
Title of host publicationPouchitis and Ileal Pouch Disorders
Subtitle of host publicationA Multidisciplinary Approach for Diagnosis and Management
PublisherElsevier
Pages119-127
Number of pages9
ISBN (Electronic)9780128094020
ISBN (Print)9780128096291
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Keywords

  • Crohn’s disease
  • Ecology
  • Idiopathic pouchitis
  • Ileal pouch
  • Microbiome

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