Microrna and other non-coding rnas in epstein–barr virus-associated cancers

Kin Israel Notarte; Suranga Senanayake; Imee Macaranas; Pia Marie Albano; Lucia Mundo; Eanna Fennell; Lorenzo Leoncini; Paul Murray

doi:10.3390/cancers13153909

Microrna and other non-coding rnas in epstein–barr virus-associated cancers

Kin Israel Notarte
, Suranga Senanayake
, Imee Macaranas
, Pia Marie Albano
, Lucia Mundo
, Eanna Fennell
, Lorenzo Leoncini
, Paul Murray

University of Santo Tomas
University College Dublin
University of Siena
University of Limerick
University of Birmingham
Palacký University Olomouc

Research output: Contribution to journal › Review article › peer-review

Abstract

EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.

Original language	English
Article number	3909
Journal	Cancers
Volume	13
Issue number	15
DOIs	https://doi.org/10.3390/cancers13153909
Publication status	Published - 1 Aug 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Burkitt lymphoma
Carcinogenesis
Classical Hodgkin’s lym-phoma
Diffuse large B-cell lymphoma
EBV
Gastric carcinoma
Immune evasion
MiRNA
MicroRNAome
Nasopharyngeal carcinoma

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10.3390/cancers13153909

Cite this

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title = "Microrna and other non-coding rnas in epstein–barr virus-associated cancers",

abstract = "EBV is a direct causative agent in around 1.5\% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.",

keywords = "Burkitt lymphoma, Carcinogenesis, Classical Hodgkin{\textquoteright}s lym-phoma, Diffuse large B-cell lymphoma, EBV, Gastric carcinoma, Immune evasion, MiRNA, MicroRNAome, Nasopharyngeal carcinoma",

author = "Notarte, \{Kin Israel\} and Suranga Senanayake and Imee Macaranas and Albano, \{Pia Marie\} and Lucia Mundo and Eanna Fennell and Lorenzo Leoncini and Paul Murray",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

day = "1",

doi = "10.3390/cancers13153909",

language = "English",

volume = "13",

journal = "Cancers",

issn = "2072-6694",

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TY - JOUR

T1 - Microrna and other non-coding rnas in epstein–barr virus-associated cancers

AU - Notarte, Kin Israel

AU - Senanayake, Suranga

AU - Macaranas, Imee

AU - Albano, Pia Marie

AU - Mundo, Lucia

AU - Fennell, Eanna

AU - Leoncini, Lorenzo

AU - Murray, Paul

PY - 2021/8/1

Y1 - 2021/8/1

N2 - EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.

AB - EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.

KW - Burkitt lymphoma

KW - Carcinogenesis

KW - Classical Hodgkin’s lym-phoma

KW - Diffuse large B-cell lymphoma

KW - EBV

KW - Gastric carcinoma

KW - Immune evasion

KW - MiRNA

KW - MicroRNAome

KW - Nasopharyngeal carcinoma

UR - https://www.scopus.com/pages/publications/85111638216

U2 - 10.3390/cancers13153909

DO - 10.3390/cancers13153909

M3 - Review article

AN - SCOPUS:85111638216

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 15

M1 - 3909

ER -

Microrna and other non-coding rnas in epstein–barr virus-associated cancers

Abstract

UN SDGs

Keywords

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