TY - JOUR
T1 - MicroRNA
T2 - Key regulators of oligodendrocyte development and pathobiology
AU - Fitzpatrick, John Mark K.
AU - Anderson, Rebecca C.
AU - McDermott, Kieran W.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/6/12
Y1 - 2015/6/12
N2 - MicroRNAs (miRNAs or miRs) are a group of small non-coding RNAs that function through binding to messenger RNA (mRNA) targets and downregulating gene expression. miRNAs have been shown to regulate many cellular functions including proliferation, differentiation, development and apoptosis. Recently, evidence has grown which shows the involvement of miRs in oligodendrocyte (OL) specification and development. In particular, miRs-138, -219, -338, and -9 have been classified as key regulators of OL development, acting at various points in the OL lineage and influencing precursor cell transit into mature myelinating OLs. Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke, spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD).
AB - MicroRNAs (miRNAs or miRs) are a group of small non-coding RNAs that function through binding to messenger RNA (mRNA) targets and downregulating gene expression. miRNAs have been shown to regulate many cellular functions including proliferation, differentiation, development and apoptosis. Recently, evidence has grown which shows the involvement of miRs in oligodendrocyte (OL) specification and development. In particular, miRs-138, -219, -338, and -9 have been classified as key regulators of OL development, acting at various points in the OL lineage and influencing precursor cell transit into mature myelinating OLs. Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke, spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD).
KW - CNS
KW - Development
KW - MicroRNA
KW - Myelination
KW - Oligodendrocyte
UR - http://www.scopus.com/inward/record.url?scp=84930943118&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2015.05.021
DO - 10.1016/j.biocel.2015.05.021
M3 - Short survey
C2 - 26026282
AN - SCOPUS:84930943118
SN - 1357-2725
VL - 65
SP - 134
EP - 138
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
ER -
