TY - JOUR
T1 - Mimicking heme enzymes in the solid state
T2 - Metal-organic materials with selectively encapsulated heme
AU - Larsen, Randy W.
AU - Wojtas, Lukasz
AU - Perman, Jason
AU - Musselman, Ronald L.
AU - Zaworotko, Michael J.
AU - Vetromile, Carissa M.
PY - 2011/7/13
Y1 - 2011/7/13
N2 - To carry out essential life processes, nature has had to evolve heme enzymes capable of synthesizing and manipulating complex molecules. These proteins perform a plethora of chemical reactions utilizing a single iron porphyrin active site embedded within an evolutionarily designed protein pocket. We herein report the first class of metal-organic materials (MOMs) that mimic heme enzymes in terms of both structure and reactivity. The MOMzyme-1 class is based upon a prototypal MOM, HKUST-1, into which catalytically active metalloporphyrins are selectively encapsulated in a ship-in-a-bottle fashion within one of the three nanoscale cages that exist in HKUST-1. MOMs offer unparalleled levels of permanent porosity and their modular nature affords enormous diversity of structures and properties. The MOMzyme-1 class could therefore represent a new paradigm for heme biomimetic catalysis since it combines the activity of a homogeneous catalyst with the stability and recyclability of heterogeneous catalytic systems within a single material.
AB - To carry out essential life processes, nature has had to evolve heme enzymes capable of synthesizing and manipulating complex molecules. These proteins perform a plethora of chemical reactions utilizing a single iron porphyrin active site embedded within an evolutionarily designed protein pocket. We herein report the first class of metal-organic materials (MOMs) that mimic heme enzymes in terms of both structure and reactivity. The MOMzyme-1 class is based upon a prototypal MOM, HKUST-1, into which catalytically active metalloporphyrins are selectively encapsulated in a ship-in-a-bottle fashion within one of the three nanoscale cages that exist in HKUST-1. MOMs offer unparalleled levels of permanent porosity and their modular nature affords enormous diversity of structures and properties. The MOMzyme-1 class could therefore represent a new paradigm for heme biomimetic catalysis since it combines the activity of a homogeneous catalyst with the stability and recyclability of heterogeneous catalytic systems within a single material.
UR - http://www.scopus.com/inward/record.url?scp=79960066021&partnerID=8YFLogxK
U2 - 10.1021/ja203068u
DO - 10.1021/ja203068u
M3 - Article
C2 - 21668010
AN - SCOPUS:79960066021
SN - 0002-7863
VL - 133
SP - 10356
EP - 10359
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 27
ER -