Mimicking heme enzymes in the solid state: Metal-organic materials with selectively encapsulated heme

Randy W. Larsen, Lukasz Wojtas, Jason Perman, Ronald L. Musselman, Michael J. Zaworotko, Carissa M. Vetromile

Research output: Contribution to journalArticlepeer-review

Abstract

To carry out essential life processes, nature has had to evolve heme enzymes capable of synthesizing and manipulating complex molecules. These proteins perform a plethora of chemical reactions utilizing a single iron porphyrin active site embedded within an evolutionarily designed protein pocket. We herein report the first class of metal-organic materials (MOMs) that mimic heme enzymes in terms of both structure and reactivity. The MOMzyme-1 class is based upon a prototypal MOM, HKUST-1, into which catalytically active metalloporphyrins are selectively encapsulated in a ship-in-a-bottle fashion within one of the three nanoscale cages that exist in HKUST-1. MOMs offer unparalleled levels of permanent porosity and their modular nature affords enormous diversity of structures and properties. The MOMzyme-1 class could therefore represent a new paradigm for heme biomimetic catalysis since it combines the activity of a homogeneous catalyst with the stability and recyclability of heterogeneous catalytic systems within a single material.

Original languageEnglish
Pages (from-to)10356-10359
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number27
DOIs
Publication statusPublished - 13 Jul 2011
Externally publishedYes

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