MitoQ loaded chitosan-hyaluronan composite membranes for wound healing

Tamer M. Tamer, Maurice N. Collins, Katarina Valachová, Mohamed A. Hassan, Ahmed M. Omer, Mohamed S. Mohy-Eldin, Karol Švík, Rastislav Jurčík, L'ubomír Ondruška, Csaba Biró, Ahmad B. Albadarin, Ladislav Šoltés

Research output: Contribution to journalArticlepeer-review

Abstract

Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant-MitoQ-was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes.

Original languageEnglish
Article number569
JournalMaterials
Volume11
Issue number4
DOIs
Publication statusPublished - 7 Apr 2018

Keywords

  • Chitosan
  • Hyaluronan
  • Mitochondrially-targeted antioxidant
  • Skin wounds

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