Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy

Björn A. Meyerson; Jian Guo Cui; Vadim Yakhnits; Alf Sollevi; Märta Segerdahl; Carl Olav Stiller; William T. O'Connor; Bengt Linderoth

doi:10.1159/000099914

Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy

Björn A. Meyerson, Jian Guo Cui, Vadim Yakhnits, Alf Sollevi, Märta Segerdahl, Carl Olav Stiller, William T. O'Connor, Bengt Linderoth

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABA(B) agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.

Original language	English
Pages (from-to)	129-140
Number of pages	12
Journal	Stereotactic and Functional Neurosurgery
Volume	68
Issue number	1-4
DOIs	https://doi.org/10.1159/000099914
Publication status	Published - 1997
Externally published	Yes

Keywords

Adenosine
Aspartate
Baclofen
GABA
Glutamate
Neuropathic pain
Spinal cord stimulation

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10.1159/000099914

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abstract = "Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABA(B) agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.",

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AU - Cui, Jian Guo

AU - Yakhnits, Vadim

AU - Sollevi, Alf

AU - Segerdahl, Märta

AU - Stiller, Carl Olav

AU - O'Connor, William T.

AU - Linderoth, Bengt

PY - 1997

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N2 - Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABA(B) agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.

AB - Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABA(B) agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.

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KW - Aspartate

KW - Baclofen

KW - GABA

KW - Glutamate

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Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy

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