Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Fatemeh Forouzanfar, George Barreto, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalBioFactors
Volume45
Issue number5
DOIs
Publication statusPublished - 1 Sep 2019
Externally publishedYes

Keywords

  • cancer
  • curcumin
  • heat shock protein
  • herbal medicine

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