TY - JOUR
T1 - Modulatory effects of curcumin on heat shock proteins in cancer
T2 - A promising therapeutic approach
AU - Forouzanfar, Fatemeh
AU - Barreto, George
AU - Majeed, Muhammed
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2019 International Union of Biochemistry and Molecular Biology
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.
AB - Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.
KW - cancer
KW - curcumin
KW - heat shock protein
KW - herbal medicine
UR - http://www.scopus.com/inward/record.url?scp=85073182612&partnerID=8YFLogxK
U2 - 10.1002/biof.1522
DO - 10.1002/biof.1522
M3 - Review article
C2 - 31136038
AN - SCOPUS:85073182612
SN - 0951-6433
VL - 45
SP - 631
EP - 640
JO - BioFactors
JF - BioFactors
IS - 5
ER -