TY - JOUR
T1 - MRI Guided Magneto-chemotherapy with High-Magnetic-Moment Iron Oxide Nanoparticles for Cancer Theranostics
AU - Salunkhe, Ashwini
AU - Khot, Vishwajeet
AU - Patil, S. I.
AU - Tofail, Syed A.M.
AU - Bauer, Joanna
AU - Thorat, Nanasaheb D.
PY - 2020/4/20
Y1 - 2020/4/20
N2 - Elevating and monitoring the temperature of tumors using magnetic nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next-generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high-magnetic-moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, we developed high-magnetic-moment iron oxide (Fe3O4) nanoparticles (NPs) using base diisopropylamine (DIPA), which plays a dual role as reducing agent and surface stabilizer. Spherical NPs with ∼12 nm size and a high magnetization value of about 92 emu g-1 at room temperature are obtained by this unique method. A high specific absorption rate value of ∼717 wg-1 was obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm-1 and frequency of 267 kHz, which is attributed to the high magnetization value. The magneto-polymeric micelle structure is formed by using Pluronic F127, and anticancer drug doxorubicin is conjugated in the micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7) cells with an overall ∼96% killing of cancer cells attained in 30 min of magneto-chmeotherapy.
AB - Elevating and monitoring the temperature of tumors using magnetic nanoparticles (MNPs) still presents a challenge in magnetic hyperthermia therapy. The efficient heating of tumor volume can be achieved by preparing MNPs with high magnetization values. The next-generation approach to magnetic resonance image (MRI)-guided magneto-chemotherapy of cancer based on high-magnetic-moment iron oxide nanoparticles is proposed. The proof of concept is validated by cellular MRI experiments on breast cancer cells. To explore magneto-chemotherapy, we developed high-magnetic-moment iron oxide (Fe3O4) nanoparticles (NPs) using base diisopropylamine (DIPA), which plays a dual role as reducing agent and surface stabilizer. Spherical NPs with ∼12 nm size and a high magnetization value of about 92 emu g-1 at room temperature are obtained by this unique method. A high specific absorption rate value of ∼717 wg-1 was obtained for Fe3O4 NPs in water at an alternating magnetic field of 20 kAm-1 and frequency of 267 kHz, which is attributed to the high magnetization value. The magneto-polymeric micelle structure is formed by using Pluronic F127, and anticancer drug doxorubicin is conjugated in the micelle by electrostatic interactions for magneto-chemotherapy. Finally, the magnetic resonance imaging (MRI)-guided magneto-chemotherapy was achieved on breast cancer (MCF7) cells with an overall ∼96% killing of cancer cells attained in 30 min of magneto-chmeotherapy.
KW - induction heating properties
KW - iron oxide nanoparticles
KW - magnetic properties
KW - nanofluids
KW - specific absorption rate
UR - http://www.scopus.com/inward/record.url?scp=85084392737&partnerID=8YFLogxK
U2 - 10.1021/acsabm.0c00077
DO - 10.1021/acsabm.0c00077
M3 - Article
C2 - 35025282
AN - SCOPUS:85084392737
SN - 2576-6422
VL - 3
SP - 2305
EP - 2313
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 4
ER -
