mRNA-based nanovaccines as newer treatment modalities in cancer

A tumor is the most malignant state in physical health and its treatment regimens are very complicated for human health. The most important part of this science is the targeted specific delivery and the hurdle relies in meantime with fewer side effects or toxicity. Recently molecular medicine put in an applied implicit in nanomedicine with a robust approach in clinical manifestations and potential outcomes in remedial for patients. In this chapter, we are going to discuss within the bounds/realms of possibility in antitumor immune therapy framework and nanocapsulated mRNA mediated therapy. Inside it, the cellular barrier hurdles for the entry of mRNA nano complex inside the body for finding the suitable route of administration. Afterward, we will discuss specific components in delivery system, lipid nanoparticle delivery mechanism, polymers to dendrimers implications at mRNA-based nanocarrier approaches in immune therapeutics, different types of mRNA vaccines (nonamplifying and self-amplifying), which can be targetable in cancer nanoengineered vaccine research in cancer. The aim is to solve patient complication and lower the treatment remedies and this can be possible via novel mRNA nanovaccine as an additive ailment in cancer immunotherapy.