Multicomponent ion exchange equilibria of weak electrolyte biomolecules

Luuk A.M. Van Der Wielen, Marcel L. Jansen, Karen Ch A.M. Luyben

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Ion exchange is one of the powerful work horses in the recovery and purification of biotechnological products, such as antibiotics, amino acids, and proteins. Rational design of bioseparation processes involving ion exchange requires the reliable description of governing equilibria. The conventional description of multicomponent ion exchange equilibria [1] is based on stoichiometric, constant selectivity models, and complete exclusion of co-ions from the resin matrix. Also, uptake mechanisms, other than ion exchange, are usually not accounted for explicitly. This general problem is illustrated for the uptake equilibria of aqueous acetic acid/acetate solutions onto strong anion exchange resins in Figure 11.1. The parameter Q is the ion exchange capacity of the resin (also called the density of fixed charges on the ion exchange matrix), CT is the anion concentration in the liquid phase,Δπ the difference in electric potential between the liquid and resin phase, and p is the osmostic effect (to be explained later).

Original languageEnglish
Title of host publicationBiothermodynamics
Subtitle of host publicationThe Role of Thermodynamics in Biochemical Engineering
PublisherPresses Polytechniques Et Universitaires Romandes
Pages245-258
Number of pages14
ISBN (Electronic)9781466582170
ISBN (Print)9781466582163
Publication statusPublished - 1 Jan 2013
Externally publishedYes

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