Multimarker Panels in Sepsis

Brian Casserly; Richard Read; Mitchell M. Levy

doi:10.1016/j.ccc.2010.12.011

Multimarker Panels in Sepsis

Brian Casserly
, Richard Read
, Mitchell M. Levy

Research output: Contribution to journal › Review article › peer-review

Abstract

Biomarkers differentiate between 2 or more biologic states. The complexity of diseases like sepsis makes it unlikely that any single marker will allow for precise disease specification. Combining several biomarkers into a single classification rule should help to improve their accuracy and, therefore, their usefulness. This article reviews several studies using multimarker panels, and highlights the potential of more sophisticated diagnostic and prognostic techniques in future multimarker panels. More complex algorithms should accelerate the adoption of multimarker panels into the routine management of patients with sepsis, provided that clinicians understand the multimarker approach.

Original language	English
Pages (from-to)	391-405
Number of pages	15
Journal	Critical Care Clinics
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.ccc.2010.12.011
Publication status	Published - Apr 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarkers
Multimarker panels
Sepsis
Statistics
Systemic inflammatory response syndrome

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10.1016/j.ccc.2010.12.011

Cite this

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title = "Multimarker Panels in Sepsis",

abstract = "Biomarkers differentiate between 2 or more biologic states. The complexity of diseases like sepsis makes it unlikely that any single marker will allow for precise disease specification. Combining several biomarkers into a single classification rule should help to improve their accuracy and, therefore, their usefulness. This article reviews several studies using multimarker panels, and highlights the potential of more sophisticated diagnostic and prognostic techniques in future multimarker panels. More complex algorithms should accelerate the adoption of multimarker panels into the routine management of patients with sepsis, provided that clinicians understand the multimarker approach.",

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AU - Casserly, Brian

AU - Read, Richard

AU - Levy, Mitchell M.

PY - 2011/4

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AB - Biomarkers differentiate between 2 or more biologic states. The complexity of diseases like sepsis makes it unlikely that any single marker will allow for precise disease specification. Combining several biomarkers into a single classification rule should help to improve their accuracy and, therefore, their usefulness. This article reviews several studies using multimarker panels, and highlights the potential of more sophisticated diagnostic and prognostic techniques in future multimarker panels. More complex algorithms should accelerate the adoption of multimarker panels into the routine management of patients with sepsis, provided that clinicians understand the multimarker approach.

KW - Biomarkers

KW - Multimarker panels

KW - Sepsis

KW - Statistics

KW - Systemic inflammatory response syndrome

UR - https://www.scopus.com/pages/publications/79953000353

U2 - 10.1016/j.ccc.2010.12.011

DO - 10.1016/j.ccc.2010.12.011

M3 - Review article

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AN - SCOPUS:79953000353

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JO - Critical Care Clinics

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IS - 2

ER -

Multimarker Panels in Sepsis

Abstract

UN SDGs

Keywords

Access to Document

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