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Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: Differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells

  • Elizabeth J. Ryan
  • , Edel Mcneela
  • , Geraldine A. Murphy
  • , Helen Stewart
  • , Derek O'Hagan
  • , Mariagrazia Pizza
  • , Rino Rappuoli
  • , Kingston H.G. Mills
  • Maynooth University
  • Novartis
  • Novartis Vaccines and Diagnostic S.r.l.

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Immunology and Microbiology

Pharmacology, Toxicology and Pharmaceutical Science