Nanobiomaterials for three-dimensional bioprinting

Sougata Ghosh, Ebrahim Mostafavi, Nanasaheb Thorat, Thomas J. Webster

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Three-dimensional (3D) bioprinting is an emerging technological innovation in tissue engineering and regenerative medicine. This process has unique control on designing 3D scaffolds with superior mechanical strength and material degradation rate apart from the modulation of the cellular microenvironment, cell adhesion, cell proliferation, tissue formation, and exchange of nutrients and waste. Thus 3D bioprinting is advantageous over conventional scaffold fabrication techniques such as phase separation, freeze drying, porogen leaching, and electrospinning. Most 3D-printed biological constructs exhibit efficient control over scaffold geometry, pore size and distribution, pore interconnectivity, as well as internal channel construction. Despite a promising future, 3D bioprinting technologies for tissue regeneration are still in their infancy due to a lack of advanced biomaterials that can recapitulate the biocompatibility, elasticity, and complexity of native structures. This chapter provides in-depth knowledge about various modalities like inkjet bioprinting, bioplotting, fused-deposition modeling, selective laser sintering, and stereolithography. Further, nanomaterials based on ceramics, polymers, collagen-fibrin hydrogel, alginate, and hyaluronic acid have been developed for the 3D bioprinting regeneration of bone, cartilage, neural, vascular and complex tissues and organs are also discussed. Finally, we emphasize the importance of the fabrication of novel biomaterials to implement advanced 3D bioprinting technology in tissue engineering and regenerative medicine.

Original languageEnglish
Title of host publicationNanotechnology in Medicine and Biology
PublisherElsevier
Pages1-24
Number of pages24
ISBN (Electronic)9780128194690
ISBN (Print)9780128226711
DOIs
Publication statusPublished - 1 Jan 2021
Externally publishedYes

Keywords

  • 3d bioprinting
  • Bioplotting
  • Electrospinning
  • Nanobiomaterials
  • Stereolithography
  • Tissue engineering

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