TY - JOUR
T1 - Nanocrystalline hydroxyapatite doped with aluminium
T2 - A potential carrier for biomedical applications
AU - Kolekar, Tanaji V.
AU - Thorat, Nanasaheb D.
AU - Yadav, Hemraj M.
AU - Magalad, Veeresh T.
AU - Shinde, Mahesh A.
AU - Bandgar, Sneha S.
AU - Kim, Jin H.
AU - Agawane, Ganesh L.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd and Techna Group S.r.l.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.
AB - Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.
KW - Apatite
KW - Biomedical applications
KW - Nanocomposites
KW - Sol-gel processes
UR - http://www.scopus.com/inward/record.url?scp=84955733388&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2015.12.060
DO - 10.1016/j.ceramint.2015.12.060
M3 - Article
AN - SCOPUS:84955733388
SN - 0272-8842
VL - 42
SP - 5304
EP - 5311
JO - Ceramics International
JF - Ceramics International
IS - 4
ER -