Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

Tanaji V. Kolekar; Nanasaheb D. Thorat; Hemraj M. Yadav; Veeresh T. Magalad; Mahesh A. Shinde; Sneha S. Bandgar; Jin H. Kim; Ganesh L. Agawane

doi:10.1016/j.ceramint.2015.12.060

Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

Tanaji V. Kolekar
, Nanasaheb D. Thorat
, Hemraj M. Yadav
, Veeresh T. Magalad
, Mahesh A. Shinde
, Sneha S. Bandgar
, Jin H. Kim
, Ganesh L. Agawane

Research output: Contribution to journal › Article › peer-review

Abstract

Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.

Original language	English
Pages (from-to)	5304-5311
Number of pages	8
Journal	Ceramics International
Volume	42
Issue number	4
DOIs	https://doi.org/10.1016/j.ceramint.2015.12.060
Publication status	Published - 1 Mar 2016
Externally published	Yes

Keywords

Apatite
Biomedical applications
Nanocomposites
Sol-gel processes

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10.1016/j.ceramint.2015.12.060

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@article{9397b37d869d43598919ac20e4405ea9,

title = "Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications",

abstract = "Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol\%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.",

keywords = "Apatite, Biomedical applications, Nanocomposites, Sol-gel processes",

author = "Kolekar, \{Tanaji V.\} and Thorat, \{Nanasaheb D.\} and Yadav, \{Hemraj M.\} and Magalad, \{Veeresh T.\} and Shinde, \{Mahesh A.\} and Bandgar, \{Sneha S.\} and Kim, \{Jin H.\} and Agawane, \{Ganesh L.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd and Techna Group S.r.l.",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.ceramint.2015.12.060",

language = "English",

volume = "42",

pages = "5304--5311",

journal = "Ceramics International",

issn = "0272-8842",

number = "4",

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TY - JOUR

T1 - Nanocrystalline hydroxyapatite doped with aluminium

T2 - A potential carrier for biomedical applications

AU - Kolekar, Tanaji V.

AU - Thorat, Nanasaheb D.

AU - Yadav, Hemraj M.

AU - Magalad, Veeresh T.

AU - Shinde, Mahesh A.

AU - Bandgar, Sneha S.

AU - Kim, Jin H.

AU - Agawane, Ganesh L.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.

AB - Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.

KW - Apatite

KW - Biomedical applications

KW - Nanocomposites

KW - Sol-gel processes

UR - https://www.scopus.com/pages/publications/84955733388

U2 - 10.1016/j.ceramint.2015.12.060

DO - 10.1016/j.ceramint.2015.12.060

M3 - Article

AN - SCOPUS:84955733388

SN - 0272-8842

VL - 42

SP - 5304

EP - 5311

JO - Ceramics International

JF - Ceramics International

IS - 4

ER -

Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

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Keywords

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