Nanomaterials and pharmacokinetics

Sandeep B. Somvanshi, Prashant B. Kharat, K. M. Jadhav, Nanasaheb D. Thorat, Helen Townley

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Nanomaterials have outstanding applications in biomedical areas, such as drug delivery agents, nanoparticles-based imaging, magnetic fluid hyperthermia, and tissue regeneration. In the line of extensive development in nanomaterials-aided drug delivery platforms, pharmacokinetic assessments have achieved greater consideration from scientists and pharmacists as a fundamental component of the study of these nanosystems. Pharmacokinetics is nothing but the study of liberation, absorption, distribution, metabolization, and excretion (i.e., LADME) of the particular drug at the molecule scale, which provides significant information about drug response and associated side effects. The utilization of nano platforms in the delivery of drugs explores new possibilities to deliver drugs in the form of particulates, which specifically alters the LADME profile. The proper information of the pharmacokinetics aspects associated with the LADME plays a vital role in designing appropriate nanomaterials-based drug delivery systems for final clinical assessments. The pharmacokinetics of the nanomaterials is primarily dependent on the adsorption of proteins, which is consecutively decided by the physicochemical properties of the nanomaterials. Thus, more insights into the interrelation between the physicochemical properties of nanomaterials and their interface with body is required to recognize and envisage the in vivo response of the nanomaterials. In this chapter, we highlight some of the recent insights of the pharmacokinetic investigations of nanomaterials. We also provide the correlation between the physicochemical properties of the nanoscale materials and their biological behavior.

Original languageEnglish
Title of host publicationNano-Pharmacokinetics and Theranostics
Subtitle of host publicationAdvancing Cancer Therapy
PublisherElsevier
Pages1-14
Number of pages14
ISBN (Electronic)9780323850506
ISBN (Print)9780323859820
DOIs
Publication statusPublished - 1 Jan 2021
Externally publishedYes

Keywords

  • drug delivery
  • Nanomaterials
  • pharmacokinetics
  • physicochemical properties

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