Abstract
Nanomaterials have outstanding applications in biomedical areas, such as drug delivery agents, nanoparticles-based imaging, magnetic fluid hyperthermia, and tissue regeneration. In the line of extensive development in nanomaterials-aided drug delivery platforms, pharmacokinetic assessments have achieved greater consideration from scientists and pharmacists as a fundamental component of the study of these nanosystems. Pharmacokinetics is nothing but the study of liberation, absorption, distribution, metabolization, and excretion (i.e., LADME) of the particular drug at the molecule scale, which provides significant information about drug response and associated side effects. The utilization of nano platforms in the delivery of drugs explores new possibilities to deliver drugs in the form of particulates, which specifically alters the LADME profile. The proper information of the pharmacokinetics aspects associated with the LADME plays a vital role in designing appropriate nanomaterials-based drug delivery systems for final clinical assessments. The pharmacokinetics of the nanomaterials is primarily dependent on the adsorption of proteins, which is consecutively decided by the physicochemical properties of the nanomaterials. Thus, more insights into the interrelation between the physicochemical properties of nanomaterials and their interface with body is required to recognize and envisage the in vivo response of the nanomaterials. In this chapter, we highlight some of the recent insights of the pharmacokinetic investigations of nanomaterials. We also provide the correlation between the physicochemical properties of the nanoscale materials and their biological behavior.
Original language | English |
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Title of host publication | Nano-Pharmacokinetics and Theranostics |
Subtitle of host publication | Advancing Cancer Therapy |
Publisher | Elsevier |
Pages | 1-14 |
Number of pages | 14 |
ISBN (Electronic) | 9780323850506 |
ISBN (Print) | 9780323859820 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Externally published | Yes |
Keywords
- drug delivery
- Nanomaterials
- pharmacokinetics
- physicochemical properties