TY - JOUR
T1 - Neuroanatomical Dysconnectivity Underlying Cognitive Deficits in Bipolar Disorder
AU - McPhilemy, Genevieve
AU - Nabulsi, Leila
AU - Kilmartin, Liam
AU - O'Hora, Denis
AU - O'Donoghue, Stefani
AU - Tronchin, Giulia
AU - Costello, Laura
AU - Najt, Pablo
AU - Ambati, Srinath
AU - Neilsen, Gráinne
AU - Creighton, Sarah
AU - Byrne, Fintan
AU - McLoughlin, James
AU - McDonald, Colm
AU - Hallahan, Brian
AU - Cannon, Dara M.
N1 - Publisher Copyright:
© 2019 Society of Biological Psychiatry
PY - 2020/2
Y1 - 2020/2
N2 - Background: Graph theory applied to brain networks is an emerging approach to understanding the brain's topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear. Methods: We examined the role of anatomical network connectivity derived from T1- and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical/subcortical bilateral brain regions delineated in the individual's own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity. Results: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD. Conclusions: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.
AB - Background: Graph theory applied to brain networks is an emerging approach to understanding the brain's topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder (BD) and recent reports of altered anatomical network organization, the association between connectivity and cognitive impairments in BD remains unclear. Methods: We examined the role of anatomical network connectivity derived from T1- and diffusion-weighted magnetic resonance imaging in impaired cognitive performance in individuals with BD (n = 32) compared with healthy control individuals (n = 38). Fractional anisotropy- and number of streamlines-weighted anatomical brain networks were generated by mapping constrained spherical deconvolution-reconstructed white matter among 86 cortical/subcortical bilateral brain regions delineated in the individual's own coordinate space. Intelligence and executive function were investigated as distributed functions using measures of global, rich-club, and interhemispheric connectivity, while memory and social cognition were examined in relation to subnetwork connectivity. Results: Lower executive functioning related to higher global clustering coefficient in participants with BD, and lower IQ performance may present with a differential relationship between global and interhemispheric efficiency in individuals with BD relative to control individuals. Spatial recognition memory accuracy and response times were similar between diagnostic groups and associated with basal ganglia and thalamus interconnectivity and connectivity within extended anatomical subnetworks in all participants. No anatomical subnetworks related to episodic memory, short-term memory, or social cognition generally or differently in BD. Conclusions: Results demonstrate selective influence of subnetwork patterns of connectivity in underlying cognitive performance generally and abnormal global topology underlying discrete cognitive impairments in BD.
KW - Bipolar disorder
KW - Cognition
KW - Diffusion magnetic resonance imaging
KW - Graph theory
KW - Network analysis
KW - Rich club
UR - http://www.scopus.com/inward/record.url?scp=85076547752&partnerID=8YFLogxK
U2 - 10.1016/j.bpsc.2019.09.004
DO - 10.1016/j.bpsc.2019.09.004
M3 - Article
C2 - 31806486
AN - SCOPUS:85076547752
SN - 2451-9022
VL - 5
SP - 152
EP - 162
JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
IS - 2
ER -