Abstract
Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.
Original language | English |
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Pages (from-to) | 3899-3906 |
Number of pages | 8 |
Journal | Current Pharmaceutical Design |
Volume | 23 |
Issue number | 26 |
DOIs | |
Publication status | Published - 2017 |
Externally published | Yes |
Keywords
- Brain injury
- Glial cells
- Hypoxia-ischemia
- Neuroprotection
- Pharmacological treatments