Neuroprotection in hypoxic-ischemic brain injury targeting glial cells

Sofia Mucci, Maria Ines Herrera, George E. Barreto, Rodolfo Kolliker-Frers, Francisco Capani

Research output: Contribution to journalReview articlepeer-review

Abstract

Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.

Original languageEnglish
Pages (from-to)3899-3906
Number of pages8
JournalCurrent Pharmaceutical Design
Volume23
Issue number26
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Brain injury
  • Glial cells
  • Hypoxia-ischemia
  • Neuroprotection
  • Pharmacological treatments

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