Neuroprotection with Estradiol in Experimental Perinatal Asphyxia: A New Approach. A New Approach.

George Barreto, Ezequiel Saraceno, Janneth Gonzalez, Rodolfo Kolliker, Rocío Castilla, Francisco Capani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Perinatal asphyxia is an obstetric complication that can induce serious complications in the central nervous system. Between 15% and 20% of newborns die immediately after birth and 25% survive with varied neurological deficits such as cerebral palsy, mental retardation and developmental delay. Although different treatments have been used, thus far only hypothermia is recommended as a routine treatment in clinical practice. In this chapter we will discuss the use of estradiol and its impact on the long-term deficits induced by perinatal asphyxia.

Original languageEnglish
Title of host publicationEstrogen Effects on Traumatic Brain Injury
Subtitle of host publicationMechanisms of Neuroprotection and Repair
PublisherElsevier Inc.
Pages113-124
Number of pages12
ISBN (Electronic)9780128017074
ISBN (Print)9780128014790
DOIs
Publication statusPublished - 8 Jan 2015
Externally publishedYes

Keywords

  • Estradiol
  • Hippocampus
  • Neuroprotection
  • Perinatal asphyxia
  • Striatum

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