TY - JOUR
T1 - NLRP3 inflammasome as a treatment target in atherosclerosis
T2 - A focus on statin therapy
AU - Parsamanesh, Negin
AU - Moossavi, Maryam
AU - Bahrami, Afsane
AU - Fereidouni, Mohammad
AU - Barreto, George
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/8
Y1 - 2019/8
N2 - Activation of NOD-like receptor (NLR)family and pyrin domain containing 3 (NLRP3)inflammasome contributes to inflammation and may lead to atherosclerosis. The NLRP3 inflammasome as a molecular platform regulates the activation of ATP signaling, K+ efflux, cathepsin-B activity, lysosomal function and pro-inflammatory cytokines (i.e. IL-1β and IL-18). Statins has been widely prescribed for the treatment of hyperlipidemia and cardiovascular diseases. In addition to lipid-lowering effect, statins have immunomodulatory, anti-inflammatory, antioxidant and antiapoptotic functions. An increasing number of studies indicated NLRP3 inflammasome and their downstream mediators as important targets for statin drugs in inflammatory diseases. In this review, we discussed different aspect of the NLRP3 inflammasome signaling pathways and focused on the effect of statin drugs on NLRP3 inflammasomes in association to atherosclerosis in order to elucidate possible targets for future research and clinical settings.
AB - Activation of NOD-like receptor (NLR)family and pyrin domain containing 3 (NLRP3)inflammasome contributes to inflammation and may lead to atherosclerosis. The NLRP3 inflammasome as a molecular platform regulates the activation of ATP signaling, K+ efflux, cathepsin-B activity, lysosomal function and pro-inflammatory cytokines (i.e. IL-1β and IL-18). Statins has been widely prescribed for the treatment of hyperlipidemia and cardiovascular diseases. In addition to lipid-lowering effect, statins have immunomodulatory, anti-inflammatory, antioxidant and antiapoptotic functions. An increasing number of studies indicated NLRP3 inflammasome and their downstream mediators as important targets for statin drugs in inflammatory diseases. In this review, we discussed different aspect of the NLRP3 inflammasome signaling pathways and focused on the effect of statin drugs on NLRP3 inflammasomes in association to atherosclerosis in order to elucidate possible targets for future research and clinical settings.
KW - Acute coronary syndrome
KW - Coronary atherosclerosis
KW - Inflammation
KW - NLRP3
KW - NOD-like receptor
UR - http://www.scopus.com/inward/record.url?scp=85065542711&partnerID=8YFLogxK
U2 - 10.1016/j.intimp.2019.05.006
DO - 10.1016/j.intimp.2019.05.006
M3 - Review article
C2 - 31100709
AN - SCOPUS:85065542711
SN - 1567-5769
VL - 73
SP - 146
EP - 155
JO - International Immunopharmacology
JF - International Immunopharmacology
ER -