Nucleolar organiser regions as predictors of outcome in prostatic carcinoma

P. Gillen; P. A. Grace; P. Dervan; M. McDermott; J. M. Smith; J. M. Fitzpatrick

doi:10.1007/BF01576767

Nucleolar organiser regions as predictors of outcome in prostatic carcinoma

P. Gillen, P. A. Grace, P. Dervan, M. McDermott, J. M. Smith, J. M. Fitzpatrick

University College Dublin

Research output: Contribution to journal › Article › peer-review

Abstract

In a study of 45 patients with prostatic carcinoma and 10 with benign hyperplasia, nucleolar organiser regions (NORs) were counted to test the hypothesis that these loops of DNA, which transcribe to ribosomal RNA, have prognostic significance. The results showed significantly higher NOR scores in patients with cancer than in those with benign hyperplasia (p<0.05), with the highest scores being recorded in those destined to develop metastases at a later date. We conclude that this technique may have prognostic significance and warrants further prospective investigation.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	World Journal of Urology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/BF01576767
Publication status	Published - Sep 1990
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF01576767

Cite this

@article{b72d1ba9dd9c4e3fb68c359932c8b0e0,

title = "Nucleolar organiser regions as predictors of outcome in prostatic carcinoma",

abstract = "In a study of 45 patients with prostatic carcinoma and 10 with benign hyperplasia, nucleolar organiser regions (NORs) were counted to test the hypothesis that these loops of DNA, which transcribe to ribosomal RNA, have prognostic significance. The results showed significantly higher NOR scores in patients with cancer than in those with benign hyperplasia (p<0.05), with the highest scores being recorded in those destined to develop metastases at a later date. We conclude that this technique may have prognostic significance and warrants further prospective investigation.",

author = "P. Gillen and Grace, {P. A.} and P. Dervan and M. McDermott and Smith, {J. M.} and Fitzpatrick, {J. M.}",

year = "1990",

month = sep,

doi = "10.1007/BF01576767",

language = "English",

volume = "8",

pages = "175--178",

journal = "World Journal of Urology",

issn = "0724-4983",

number = "3",

}

TY - JOUR

T1 - Nucleolar organiser regions as predictors of outcome in prostatic carcinoma

AU - Gillen, P.

AU - Grace, P. A.

AU - Dervan, P.

AU - McDermott, M.

AU - Smith, J. M.

AU - Fitzpatrick, J. M.

PY - 1990/9

Y1 - 1990/9

N2 - In a study of 45 patients with prostatic carcinoma and 10 with benign hyperplasia, nucleolar organiser regions (NORs) were counted to test the hypothesis that these loops of DNA, which transcribe to ribosomal RNA, have prognostic significance. The results showed significantly higher NOR scores in patients with cancer than in those with benign hyperplasia (p<0.05), with the highest scores being recorded in those destined to develop metastases at a later date. We conclude that this technique may have prognostic significance and warrants further prospective investigation.

AB - In a study of 45 patients with prostatic carcinoma and 10 with benign hyperplasia, nucleolar organiser regions (NORs) were counted to test the hypothesis that these loops of DNA, which transcribe to ribosomal RNA, have prognostic significance. The results showed significantly higher NOR scores in patients with cancer than in those with benign hyperplasia (p<0.05), with the highest scores being recorded in those destined to develop metastases at a later date. We conclude that this technique may have prognostic significance and warrants further prospective investigation.

UR - http://www.scopus.com/inward/record.url?scp=0025124056&partnerID=8YFLogxK

U2 - 10.1007/BF01576767

DO - 10.1007/BF01576767

M3 - Article

AN - SCOPUS:0025124056

SN - 0724-4983

VL - 8

SP - 175

EP - 178

JO - World Journal of Urology

JF - World Journal of Urology

IS - 3

ER -

Nucleolar organiser regions as predictors of outcome in prostatic carcinoma

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this