TY - JOUR
T1 - NUIG4: A biocompatible pcu metalâorganic framework with an exceptional doxorubicin encapsulation capacity
AU - Ahmed, Ahmed
AU - Efthymiou, Constantinos G.
AU - Sanii, Rana
AU - Patyk-Kazmierczak, Ewa
AU - Alsharabasy, Amir M.
AU - Winterlich, Meghan
AU - Kumar, Naveen
AU - Sensharma, Debobroto
AU - Tong, Wenming
AU - Guerin, Sarah
AU - Farras, Pau
AU - Hudson, Sarah
AU - Thompson, Damien
AU - Zaworotko, Michael J.
AU - Tasiopoulos, Anastasios J.
AU - Papatriantafyllopoulou, Constantina
PY - 2022/3/2
Y1 - 2022/3/2
N2 - Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.
AB - Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2.
UR - https://www.scopus.com/pages/publications/85125554229
U2 - 10.1039/d1tb02176a
DO - 10.1039/d1tb02176a
M3 - Article
C2 - 35080573
AN - SCOPUS:85125554229
SN - 2050-750X
VL - 10
SP - 1378
EP - 1385
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 9
ER -