TY - JOUR
T1 - Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution
AU - Macchi, Edoardo Gino
AU - Tosi, Daniele
AU - Braschi, Giovanni
AU - Gallati, Mario
AU - Cigada, Alfredo
AU - Busca, Giorgio
AU - Lewis, Elfed
N1 - Publisher Copyright:
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6°C/mm) and temporal (up to 1°C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models.
AB - Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6°C/mm) and temporal (up to 1°C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models.
KW - Distributed temperature sensor
KW - Ex vivo liver tissue
KW - Fiber optic sensors
KW - Radiofrequency thermal ablation
KW - Rayleigh backscattering
UR - http://www.scopus.com/inward/record.url?scp=84910685622&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.19.11.117004
DO - 10.1117/1.JBO.19.11.117004
M3 - Article
C2 - 25388811
AN - SCOPUS:84910685622
SN - 1083-3668
VL - 19
SP - 117004
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 11
M1 - 117004
ER -