TY - JOUR
T1 - Optimisation, antioxidant attributes, stability and release behaviour of carboxymethyl cellulose films incorporated with nanoencapsulated vitamin E
AU - Mirzaei-Mohkam, Ali
AU - Garavand, Farhad
AU - Dehnad, Danial
AU - Keramat, Javad
AU - Nasirpour, Ali
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/9
Y1 - 2019/9
N2 - The aim of the current study was to optimize vitamin E (α-tocopherol)loaded polycaprolactone (PCL)nanocapsules into the carboxymethyl cellulose (CMC)film. For this purpose, polycaprolactone concentration, α-tocopherol level, and lecithin concentration were selected as independent variables, and encapsulation efficiency and nanocapsule size designated as dependent variables. The organization of experiments was carried out using response surface methodology and Box-Behnken design. Afterwards, the α-tocopherol nanocapsule loaded CMC films subjected to antioxidant test, release test and release kinetics. From the results, the encapsulation efficiency of films containing 30–70% α-tocopherol nanocapsules was varied between 88.43 and 99.66%. The enlarged nanocapsules with the enhanced encapsulation efficiency were obtained by increasing in PCL concentration, while increase in α-tocopherol concentration caused a drop in encapsulation efficiency accompanied by distended particle size. The variation in lecithin concentration wasn't significantly (p < 0.05)impact on encapsulation efficiency and nanocapsule size. The desirability function suggested the following concentrations of variables: 75.33 mg of PCL, 200 mg of α-tocopherol, and 2 mg mL−1 of lecithin. Antioxidant potential of CMC films followed a linear pattern with the addition of more α-tocopherol nanocapsules, so that films containing 70% nanocapsules showed the highest radical scavenging activity of 68.85%.
AB - The aim of the current study was to optimize vitamin E (α-tocopherol)loaded polycaprolactone (PCL)nanocapsules into the carboxymethyl cellulose (CMC)film. For this purpose, polycaprolactone concentration, α-tocopherol level, and lecithin concentration were selected as independent variables, and encapsulation efficiency and nanocapsule size designated as dependent variables. The organization of experiments was carried out using response surface methodology and Box-Behnken design. Afterwards, the α-tocopherol nanocapsule loaded CMC films subjected to antioxidant test, release test and release kinetics. From the results, the encapsulation efficiency of films containing 30–70% α-tocopherol nanocapsules was varied between 88.43 and 99.66%. The enlarged nanocapsules with the enhanced encapsulation efficiency were obtained by increasing in PCL concentration, while increase in α-tocopherol concentration caused a drop in encapsulation efficiency accompanied by distended particle size. The variation in lecithin concentration wasn't significantly (p < 0.05)impact on encapsulation efficiency and nanocapsule size. The desirability function suggested the following concentrations of variables: 75.33 mg of PCL, 200 mg of α-tocopherol, and 2 mg mL−1 of lecithin. Antioxidant potential of CMC films followed a linear pattern with the addition of more α-tocopherol nanocapsules, so that films containing 70% nanocapsules showed the highest radical scavenging activity of 68.85%.
KW - Carboxymethyl cellulose
KW - Encapsulation efficiency
KW - Film
KW - α-Tocopherol
UR - http://www.scopus.com/inward/record.url?scp=85065825389&partnerID=8YFLogxK
U2 - 10.1016/j.porgcoat.2019.05.026
DO - 10.1016/j.porgcoat.2019.05.026
M3 - Article
AN - SCOPUS:85065825389
SN - 0300-9440
VL - 134
SP - 333
EP - 341
JO - Progress in Organic Coatings
JF - Progress in Organic Coatings
ER -