Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools

Yazan Odeh; Debleena Mitra; Mohammad O.A. Malik; Douglas R. Marques; Rabah Mouras; Marion McAfee

doi:10.3303/CET25117206

Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools

Yazan Odeh
, Debleena Mitra
, Mohammad O.A. Malik
, Douglas R. Marques
, Rabah Mouras
, Marion McAfee

Atlantic Technological University
University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.

Original language	English
Pages (from-to)	1231-1236
Number of pages	6
Journal	Chemical Engineering Transactions
Volume	117
DOIs	https://doi.org/10.3303/CET25117206
Publication status	Published - 2025

Access to Document

10.3303/CET25117206

Cite this

@article{a36b0f8be77741ceb69b3507eb272aba,

title = "Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools",

abstract = "In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.",

author = "Yazan Odeh and Debleena Mitra and Malik, \{Mohammad O.A.\} and Marques, \{Douglas R.\} and Rabah Mouras and Marion McAfee",

note = "Publisher Copyright: Copyright {\textcopyright} 2025, AIDIC Servizi S.r.l.",

year = "2025",

doi = "10.3303/CET25117206",

language = "English",

volume = "117",

pages = "1231--1236",

journal = "Chemical Engineering Transactions",

issn = "2283-9216",

}

TY - JOUR

T1 - Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools

AU - Odeh, Yazan

AU - Mitra, Debleena

AU - Malik, Mohammad O.A.

AU - Marques, Douglas R.

AU - Mouras, Rabah

AU - McAfee, Marion

PY - 2025

Y1 - 2025

N2 - In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.

AB - In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.

UR - https://www.scopus.com/pages/publications/105012525599

U2 - 10.3303/CET25117206

DO - 10.3303/CET25117206

M3 - Article

AN - SCOPUS:105012525599

SN - 2283-9216

VL - 117

SP - 1231

EP - 1236

JO - Chemical Engineering Transactions

JF - Chemical Engineering Transactions

ER -

Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools

Abstract

Access to Document

Other files and links

Fingerprint

Cite this