TY - JOUR
T1 - Optimising Extrusion-Based Pla-Asa 3D Printed Drug Delivery Mesh using Pat Tools
AU - Odeh, Yazan
AU - Mitra, Debleena
AU - Malik, Mohammad O.A.
AU - Marques, Douglas R.
AU - Mouras, Rabah
AU - McAfee, Marion
N1 - Publisher Copyright:
Copyright © 2025, AIDIC Servizi S.r.l.
PY - 2025
Y1 - 2025
N2 - In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.
AB - In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined. Hot Melt extrusion (HME) significantly improves the solubility and bioavailability of poorly soluble drugs, while 3D printing enables personalised drug dosage, geometry, and mechanical properties. PLA is biodegradable and has properties that allow cellular attachment and tissue regeneration; while ASA is a substance that promotes bone regeneration and decreases associated infections. Surgical meshes for bone tissue repair and drug delivery are created through Hot Melt Extrusion (HME) and Fused Deposition Modelling (FDM) 3D printing. This work investigates the production of PLA-ASA filament using a low-cost single-screw filament extruder, the effects of 3D printing temperature on ASA stability using Raman Spectroscopy, and the flexibility and integrity of 3D printed PLA-ASA mesh.
UR - https://www.scopus.com/pages/publications/105012525599
U2 - 10.3303/CET25117206
DO - 10.3303/CET25117206
M3 - Article
AN - SCOPUS:105012525599
SN - 2283-9216
VL - 117
SP - 1231
EP - 1236
JO - Chemical Engineering Transactions
JF - Chemical Engineering Transactions
ER -