TY - JOUR
T1 - Partition Coefficients and Solubilities of α-Amino Acids in Aqueous 1-Butanol Solutions
AU - Gude, Michael T.
AU - Meuwissen, Harald H.J.
AU - Van Der Wielen, Luuk A.M.
AU - Luyben, Karel Ch A.M.
PY - 1996/12
Y1 - 1996/12
N2 - The partition coefficients of seven α-amino acids in the system water + 1-butanol have been measured at 25 °C from the very dilute region up to saturation. The solubilities of these amino acids in the pure solvents and in the miscible composition range of the solvent system have also been studied in this work. It was found that the partition coefficients of the amino acids and the composition of the phase-partitioning system are strongly dependent on the amino acid concentration and on the chemical nature of their side-chain moiety. The experimental data were successfully correlated with a thermodynamic model which describes conveniently defined excess solubilities via a simple excess Gibbs energy model having a single amino acid specific parameter. In addition, a simple method for the estimation of the solubility of amino acids in pure alkanols is presented.
AB - The partition coefficients of seven α-amino acids in the system water + 1-butanol have been measured at 25 °C from the very dilute region up to saturation. The solubilities of these amino acids in the pure solvents and in the miscible composition range of the solvent system have also been studied in this work. It was found that the partition coefficients of the amino acids and the composition of the phase-partitioning system are strongly dependent on the amino acid concentration and on the chemical nature of their side-chain moiety. The experimental data were successfully correlated with a thermodynamic model which describes conveniently defined excess solubilities via a simple excess Gibbs energy model having a single amino acid specific parameter. In addition, a simple method for the estimation of the solubility of amino acids in pure alkanols is presented.
UR - http://www.scopus.com/inward/record.url?scp=0030386956&partnerID=8YFLogxK
U2 - 10.1021/ie960031w
DO - 10.1021/ie960031w
M3 - Article
AN - SCOPUS:0030386956
SN - 0888-5885
VL - 35
SP - 4700
EP - 4712
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 12
ER -