Pathophysiology of coronavirus disease 2019 (COVID-19)

Rajkishor Pandey; Arvind K.Singh Chandel; Simran Sharma

doi:10.1088/978-0-7503-4987-1ch15

Pathophysiology of coronavirus disease 2019 (COVID-19)

Rajkishor Pandey
, Arvind K.Singh Chandel
, Simran Sharma

University of Missouri
The University of Tokyo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter provides an in-depth exploration of the pathophysiology of coronavirus disease 2019 (COVID-19), focusing on the intricate biological mechanisms of infection induced by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The discussion begins with an analysis of the virus's structural characteristics, its genetic adaptability, and the critical role of the spike protein in facilitating host cell entry through ACE2 receptors. It extends to the virus's ability to affect multiple organ systems, including the respiratory, cardiovascular, endocrine, and gastrointestinal systems, leading to a wide array of clinical manifestations. The chapter emphasizes the disruption of the renin–angiotensin system and the consequent metabolic and functional abnormalities in affected organs.

Original language	English
Title of host publication	Viral Diseases
Subtitle of host publication	History and New Developments in Diagnostics and Therapeutics
Publisher	Institute of Physics Publishing
Pages	1-10
Number of pages	10
ISBN (Electronic)	9780750349895
ISBN (Print)	9780750349857
DOIs	https://doi.org/10.1088/978-0-7503-4987-1ch15
Publication status	Published - 1 Jan 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1088/978-0-7503-4987-1ch15

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ER -

Pathophysiology of coronavirus disease 2019 (COVID-19)

Abstract

UN SDGs

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