Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Marianne Horgan, Gary O'Flynn, Jennifer Garry, Jakki Cooney, Aidan Coffey, Gerald F. Fitzgerald, R. Paul Ross, Olivia McAuliffe

Research output: Contribution to journalArticlepeer-review

Abstract

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

Original languageEnglish
Pages (from-to)872-874
Number of pages3
JournalApplied and Environmental Microbiology
Volume75
Issue number3
DOIs
Publication statusPublished - Feb 2009

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