Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Marianne Horgan; Gary O'Flynn; Jennifer Garry; Jakki Cooney; Aidan Coffey; Gerald F. Fitzgerald; R. Paul Ross; Olivia McAuliffe

doi:10.1128/AEM.01831-08

Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Marianne Horgan
, Gary O'Flynn
, Jennifer Garry
, Jakki Cooney
, Aidan Coffey
, Gerald F. Fitzgerald
, R. Paul Ross
, Olivia McAuliffe

Teagasc - Irish Agriculture and Food Development Authority
University College Cork
Munster Technological University

Research output: Contribution to journal › Article › peer-review

Abstract

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

Original language	English
Pages (from-to)	872-874
Number of pages	3
Journal	Applied and Environmental Microbiology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1128/AEM.01831-08
Publication status	Published - Feb 2009

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abstract = "A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.",

author = "Marianne Horgan and Gary O'Flynn and Jennifer Garry and Jakki Cooney and Aidan Coffey and Fitzgerald, \{Gerald F.\} and \{Paul Ross\}, R. and Olivia McAuliffe",

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AU - Horgan, Marianne

AU - O'Flynn, Gary

AU - Garry, Jennifer

AU - Cooney, Jakki

AU - Coffey, Aidan

AU - Fitzgerald, Gerald F.

AU - Paul Ross, R.

AU - McAuliffe, Olivia

PY - 2009/2

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AB - A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

UR - https://www.scopus.com/pages/publications/59649128479

U2 - 10.1128/AEM.01831-08

DO - 10.1128/AEM.01831-08

M3 - Article

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AN - SCOPUS:59649128479

SN - 0099-2240

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JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

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ER -

Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Abstract

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