TY - JOUR
T1 - Pharmacological and cellular therapies to prevent restenosis after percutaneous transluminal angioplasty and stenting
AU - Kiernan, Thomas J.
AU - Yan, Bryan P.
AU - Cruz-Gonzalez, Ignacio
AU - Cubeddu, Roberto J.
AU - Caldera, Angel
AU - Kiernan, Gareth D.
AU - Gupta, Vishal
PY - 2008/4
Y1 - 2008/4
N2 - Angioplasty and stenting have become routine practice for the treatment of significant obstructive atherosclerotic vascular disease. This method of revascularization has a longer history concerning coronary artery disease but is becoming an increasingly used modality of revascularization in the peripheral circulation. Neointimal formation is the pathological basis for restenosis after revascularization procedures such as angioplasty, stenting, and bypass grafting. While restenosis is less of a problem in the coronary circulation with the advent of drug-eluting stents, it continues to be a problem however in the peripheral arterial system. Current treatments to prevent restenosis include pharmacologic, mechanical and cellular approaches which we will discuss in this manuscript.
AB - Angioplasty and stenting have become routine practice for the treatment of significant obstructive atherosclerotic vascular disease. This method of revascularization has a longer history concerning coronary artery disease but is becoming an increasingly used modality of revascularization in the peripheral circulation. Neointimal formation is the pathological basis for restenosis after revascularization procedures such as angioplasty, stenting, and bypass grafting. While restenosis is less of a problem in the coronary circulation with the advent of drug-eluting stents, it continues to be a problem however in the peripheral arterial system. Current treatments to prevent restenosis include pharmacologic, mechanical and cellular approaches which we will discuss in this manuscript.
UR - http://www.scopus.com/inward/record.url?scp=46649095011&partnerID=8YFLogxK
U2 - 10.2174/187152508783955033
DO - 10.2174/187152508783955033
M3 - Review article
C2 - 18473776
AN - SCOPUS:46649095011
SN - 1871-5257
VL - 6
SP - 116
EP - 124
JO - Cardiovascular and Hematological Agents in Medicinal Chemistry
JF - Cardiovascular and Hematological Agents in Medicinal Chemistry
IS - 2
ER -