Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

Irena Žuntar; Adela Krivohlavek; Josipa Kosić-Vukšić; Daniel Granato; Danijela Bursać Kovačević; Predrag Putnik

doi:10.1016/j.cofs.2018.10.012

Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

Irena Žuntar
, Adela Krivohlavek
, Josipa Kosić-Vukšić
, Daniel Granato
, Danijela Bursać Kovačević
, Predrag Putnik

University of Zagreb
Teaching Institute of Public Health “Andrija Štampar”
Universidade Estadual de Ponta Grossa

Research output: Contribution to journal › Review article › peer-review

Abstract

Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as ‘healthier’ and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Current Opinion in Food Science
Volume	24
DOIs	https://doi.org/10.1016/j.cofs.2018.10.012
Publication status	Published - Dec 2018
Externally published	Yes

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10.1016/j.cofs.2018.10.012

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title = "Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications",

abstract = "Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as {\textquoteleft}healthier{\textquoteright} and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.",

author = "Irena {\v Z}untar and Adela Krivohlavek and Josipa Kosi{\'c}-Vuk{\v s}i{\'c} and Daniel Granato and \{Bursa{\'c} Kova{\v c}evi{\'c}\}, Danijela and Predrag Putnik",

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doi = "10.1016/j.cofs.2018.10.012",

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AU - Žuntar, Irena

AU - Krivohlavek, Adela

AU - Kosić-Vukšić, Josipa

AU - Granato, Daniel

AU - Bursać Kovačević, Danijela

AU - Putnik, Predrag

PY - 2018/12

Y1 - 2018/12

N2 - Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as ‘healthier’ and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.

AB - Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as ‘healthier’ and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.

UR - https://www.scopus.com/pages/publications/85055864548

U2 - 10.1016/j.cofs.2018.10.012

DO - 10.1016/j.cofs.2018.10.012

M3 - Review article

AN - SCOPUS:85055864548

SN - 2214-7993

VL - 24

SP - 9

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JO - Current Opinion in Food Science

JF - Current Opinion in Food Science

ER -

Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

Abstract

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