Photo-cross-linkable hyaluronic acid bioinks for bone and cartilage tissue engineering applications

Farnaz Ghorbani, Behafarid Ghalandari, Mehran Khajehmohammadi, Negar Bakhtiary, Hamidreza Tolabi, Melika Sahranavard, Sonia Fathi-Karkan, Vida Nazar, Shalaleh Hasan Niari Niar, Amirhosein Armoon, Maryam Ettelaei, Milad Tavakoli Banizi, Maurice N. Collins

Research output: Contribution to journalArticlepeer-review

Abstract

Hyaluronic acid (HA) is of immense importance to biomaterials science and biomedical engineering. It is finding applications in diverse areas of bioengineering ranging from scaffolds for disease modelling to tissue culture for reconstruction. This review focuses on recent research on the role of HA as a photo-cross-linked bioink and its importance in combating bone and cartilage-related disease, injury and disorders. Photo chemical modifications and 3D fabrication technologies employed to produce HA-modified materials are analysed to provide a fundamental understanding of the structure–function-property relationships that influence printability, shape fidelity and biological performance both in-vitro and in-vivo. The article concludes with a future vision for HA-based bioinks and their deployment in light-based bioprinting technologies for bone and cartilage repair.

Original languageEnglish
Pages (from-to)901-942
Number of pages42
JournalInternational Materials Reviews
Volume68
Issue number7
DOIs
Publication statusPublished - 2023

Keywords

  • 3D-print
  • Hyaluronic acid
  • bioink
  • bioprint
  • bone
  • cartilage
  • photo-cross-linkable
  • tissue engineering

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