TY - JOUR
T1 - Photoactivated titania-based nanomaterials for potential application as cardiovascular stent coatings
AU - Kopaczyńska, Marta
AU - Sobieszczańska, Beata
AU - Ulatowska-Jarza, Agnieszka
AU - Hołowacz, Iwona
AU - Buzalewicz, Igor
AU - Wasyluk, Łukasz
AU - Tofail, Syed A.M.
AU - Biały, Dariusz
AU - Wawrzyńska, Magdalena
AU - Podbielska, Halina
PY - 2014
Y1 - 2014
N2 - Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis highlight the importance of meeting the excellent biocompatibility by cardiovascular implants. Many attempts have been made to improve the safety profile of implant surface. We for the first time developed the photoactive intravascular titania-based nanomaterials for the application as cardiovascular stent coating. Photoactive biomaterial deposited on the cardiovascular stent surface demonstrated promising features, making it an excellent substrate for endothelial cells growth and proliferation. The biocompatibility of these coatings has been compared with 316L stainless steel surfaces typically used in commercial coronary stents production. The results of the study proved that the innovative titania-based coatings have better biocompatibility characteristics than the 316L stainless steel and in regard of its antithrombotic potential provided protection against restenosis. Furthermore, the titania coating supported endothelial cells attachment and proliferation, and induced prolonged plasma recalcification time in comparison with stainless steel surface. Innovative photoactive titania coating can be an important factor to prevent the process of the restenosis in the place of implantation.
AB - Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis highlight the importance of meeting the excellent biocompatibility by cardiovascular implants. Many attempts have been made to improve the safety profile of implant surface. We for the first time developed the photoactive intravascular titania-based nanomaterials for the application as cardiovascular stent coating. Photoactive biomaterial deposited on the cardiovascular stent surface demonstrated promising features, making it an excellent substrate for endothelial cells growth and proliferation. The biocompatibility of these coatings has been compared with 316L stainless steel surfaces typically used in commercial coronary stents production. The results of the study proved that the innovative titania-based coatings have better biocompatibility characteristics than the 316L stainless steel and in regard of its antithrombotic potential provided protection against restenosis. Furthermore, the titania coating supported endothelial cells attachment and proliferation, and induced prolonged plasma recalcification time in comparison with stainless steel surface. Innovative photoactive titania coating can be an important factor to prevent the process of the restenosis in the place of implantation.
KW - Biocompatibility
KW - Cardiovascular stent
KW - Endothelial cells
KW - Photoactive coating
KW - Surface charge
UR - http://www.scopus.com/inward/record.url?scp=84905568628&partnerID=8YFLogxK
U2 - 10.1016/j.bbe.2014.03.005
DO - 10.1016/j.bbe.2014.03.005
M3 - Article
AN - SCOPUS:84905568628
SN - 0208-5216
VL - 34
SP - 189
EP - 197
JO - Biocybernetics and Biomedical Engineering
JF - Biocybernetics and Biomedical Engineering
IS - 3
ER -