Photochemical generation and reactions of heme cation radicals in heme proteins

Edmond Magner, George McLendon

Research output: Contribution to journalArticlepeer-review

Abstract

A novel approach is described for generating reactive oxidizing centers in heme proteins, with zinc hemoglobin (Zn Hb) and zinc cytochrome c (Zn cyt c) used as examples. The reaction of 3Zn* Hb with [CoIII(NH3)5 Cl]2+, and of 3Zn* cyt c with methyl viologen are described. In the case of Zn Hb the cation radical produced decays with a rate constant of k3 = 2400s-1. Using this value the rate of the reaction αZn+.βFe(III), k2αZnβ Fe(III) can be calculated to be 4500s-1.

Original languageEnglish
Pages (from-to)472-476
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume159
Issue number2
DOIs
Publication statusPublished - 15 Mar 1989
Externally publishedYes

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