Photochemical generation and reactions of heme cation radicals in heme proteins

Edmond Magner; George McLendon

doi:10.1016/0006-291X(89)90016-8

Photochemical generation and reactions of heme cation radicals in heme proteins

Edmond Magner
, George McLendon

University of Rochester

Research output: Contribution to journal › Article › peer-review

Abstract

A novel approach is described for generating reactive oxidizing centers in heme proteins, with zinc hemoglobin (Zn Hb) and zinc cytochrome c (Zn cyt c) used as examples. The reaction of ³Zn^* Hb with [Co^III(NH₃)₅ Cl]²⁺, and of ³Zn^* cyt c with methyl viologen are described. In the case of Zn Hb the cation radical produced decays with a rate constant of k₃ = 2400s^-1. Using this value the rate of the reaction α^Zn+.β^Fe(III), ^k₂_→α^Znβ^Fe(III) can be calculated to be 4500s^-1.

Original language	English
Pages (from-to)	472-476
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	159
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(89)90016-8
Publication status	Published - 15 Mar 1989
Externally published	Yes

Access to Document

10.1016/0006-291X(89)90016-8

Cite this

@article{5bab888ce5534d0791cb3530ddc19765,

title = "Photochemical generation and reactions of heme cation radicals in heme proteins",

abstract = "A novel approach is described for generating reactive oxidizing centers in heme proteins, with zinc hemoglobin (Zn Hb) and zinc cytochrome c (Zn cyt c) used as examples. The reaction of 3Zn* Hb with [CoIII(NH3)5 Cl]2+, and of 3Zn* cyt c with methyl viologen are described. In the case of Zn Hb the cation radical produced decays with a rate constant of k3 = 2400s-1. Using this value the rate of the reaction αZn+.βFe(III), k2→αZnβ Fe(III) can be calculated to be 4500s-1.",

author = "Edmond Magner and George McLendon",

year = "1989",

month = mar,

day = "15",

doi = "10.1016/0006-291X(89)90016-8",

language = "English",

volume = "159",

pages = "472--476",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

number = "2",

}

TY - JOUR

T1 - Photochemical generation and reactions of heme cation radicals in heme proteins

AU - Magner, Edmond

AU - McLendon, George

PY - 1989/3/15

Y1 - 1989/3/15

N2 - A novel approach is described for generating reactive oxidizing centers in heme proteins, with zinc hemoglobin (Zn Hb) and zinc cytochrome c (Zn cyt c) used as examples. The reaction of 3Zn* Hb with [CoIII(NH3)5 Cl]2+, and of 3Zn* cyt c with methyl viologen are described. In the case of Zn Hb the cation radical produced decays with a rate constant of k3 = 2400s-1. Using this value the rate of the reaction αZn+.βFe(III), k2→αZnβ Fe(III) can be calculated to be 4500s-1.

AB - A novel approach is described for generating reactive oxidizing centers in heme proteins, with zinc hemoglobin (Zn Hb) and zinc cytochrome c (Zn cyt c) used as examples. The reaction of 3Zn* Hb with [CoIII(NH3)5 Cl]2+, and of 3Zn* cyt c with methyl viologen are described. In the case of Zn Hb the cation radical produced decays with a rate constant of k3 = 2400s-1. Using this value the rate of the reaction αZn+.βFe(III), k2→αZnβ Fe(III) can be calculated to be 4500s-1.

UR - https://www.scopus.com/pages/publications/0024598912

U2 - 10.1016/0006-291X(89)90016-8

DO - 10.1016/0006-291X(89)90016-8

M3 - Article

C2 - 2539112

AN - SCOPUS:0024598912

SN - 0006-291X

VL - 159

SP - 472

EP - 476

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Photochemical generation and reactions of heme cation radicals in heme proteins

Abstract

Access to Document

Other files and links

Fingerprint

Cite this