Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

U. B.Rao Khandavilli; Mustafa Yousuf; Barbara E. Schaller; René R.E. Steendam; Leila Keshavarz; Patrick McArdle; Patrick J. Frawley

doi:10.1039/c9ce01625b

Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

U. B.Rao Khandavilli, Mustafa Yousuf, Barbara E. Schaller, René R.E. Steendam, Leila Keshavarz, Patrick McArdle, Patrick J. Frawley

Research output: Contribution to journal › Article › peer-review

Abstract

Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form.

Original language	English
Pages (from-to)	412-415
Number of pages	4
Journal	CrystEngComm
Volume	22
Issue number	3
DOIs	https://doi.org/10.1039/c9ce01625b
Publication status	Published - 2020

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10.1039/c9ce01625b

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title = "Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility",

abstract = "Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form.",

author = "Khandavilli, {U. B.Rao} and Mustafa Yousuf and Schaller, {Barbara E.} and Steendam, {Ren{\'e} R.E.} and Leila Keshavarz and Patrick McArdle and Frawley, {Patrick J.}",

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T1 - Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

AU - Khandavilli, U. B.Rao

AU - Yousuf, Mustafa

AU - Schaller, Barbara E.

AU - Steendam, René R.E.

AU - Keshavarz, Leila

AU - McArdle, Patrick

AU - Frawley, Patrick J.

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry.

PY - 2020

Y1 - 2020

N2 - Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form.

AB - Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coformers oxalic acid and salicylic acid. These mechanically flexible salts show improved solubility, tabletability and compressibility compared to the marketed anhydrous form.

UR - http://www.scopus.com/inward/record.url?scp=85078099419&partnerID=8YFLogxK

U2 - 10.1039/c9ce01625b

DO - 10.1039/c9ce01625b

M3 - Article

AN - SCOPUS:85078099419

SN - 1466-8033

VL - 22

SP - 412

EP - 415

JO - CrystEngComm

JF - CrystEngComm

IS - 3

ER -

Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility

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