Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

D.F. Silva; C.Q. Alves; H.N. Brandão; J.M. David; J.P. David; R.L. Silva; M. Franchin; T.M. Cunha; F.T. Martins; C.M.A. Oliveira

doi:10.1016/j.fitote.2016.07.021

Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

D.F. Silva
, C.Q. Alves
, H.N. Brandão
, J.M. David
, J.P. David
, R.L. Silva
, M. Franchin
, T.M. Cunha
, F.T. Martins
, C.M.A. Oliveira

Department of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	Fitoterapia
Volume	113
DOIs	https://doi.org/10.1016/j.fitote.2016.07.021
Publication status	Published - 1 Sep 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.fitote.2016.07.021

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title = "Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation",

abstract = "An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.",

author = "D.F. Silva and C.Q. Alves and H.N. Brand{\~a}o and J.M. David and J.P. David and R.L. Silva and M. Franchin and T.M. Cunha and F.T. Martins and C.M.A. Oliveira",

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TY - JOUR

T1 - Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

AU - Silva, D.F.

AU - Alves, C.Q.

AU - Brandão, H.N.

AU - David, J.M.

AU - David, J.P.

AU - Silva, R.L.

AU - Franchin, M.

AU - Cunha, T.M.

AU - Martins, F.T.

AU - Oliveira, C.M.A.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.

AB - An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84980336417&partnerID=MN8TOARS

U2 - 10.1016/j.fitote.2016.07.021

DO - 10.1016/j.fitote.2016.07.021

M3 - Article

VL - 113

SP - 139

EP - 143

JO - Fitoterapia

JF - Fitoterapia

ER -

Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation

Abstract

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