TY - JOUR
T1 - Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation
AU - Silva, D.F.
AU - Alves, C.Q.
AU - Brandão, H.N.
AU - David, J.M.
AU - David, J.P.
AU - Silva, R.L.
AU - Franchin, M.
AU - Cunha, T.M.
AU - Martins, F.T.
AU - Oliveira, C.M.A.
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.
AB - An unusually substituted coumarin, named poligalen, was isolated from a chloroform extract of the aerial parts of Polygala boliviensis. This coumarin was identified by one- and two-dimensional NMR techniques, and the structure of the compound was confirmed by X-ray diffraction. Poligalen exhibits immunomodulatory effects, reducing the levels of IL-6 and TNF after LPS stimulation in peritoneal macrophages. However, poligalen potentiates NF-kB activation.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84980336417&partnerID=MN8TOARS
U2 - 10.1016/j.fitote.2016.07.021
DO - 10.1016/j.fitote.2016.07.021
M3 - Article
VL - 113
SP - 139
EP - 143
JO - Fitoterapia
JF - Fitoterapia
ER -
