Poly(ethylene glycol)-salt aqueous two-phase systems with easily recyclable volatile salts

Mos Van Berlo, Karel Ch A.M. Luyben, Luuk A.M. Van Der Wielen

Research output: Contribution to journalArticlepeer-review

Abstract

Aqueous two-phase systems (ATPSs) have great potential in the downstream processing of fermentation products. However, the consumption of large amounts of auxiliary materials limits application in industrial practice. Promising alternatives to the salts used so far are volatile salts such as ammonium bicarbonate and ammonium carbamate, which can be recycled to the extraction system as gaseous carbon dioxide and ammonia. In this work, it is demonstrated that ammonium carbamate in combination with poly(ethylene glycol) (PEG, molecular masses of 2000, 4000 and 10 000) indeed produces aqueous two-phase systems (ATPSs) at a temperature of 25°C and atmospheric pressure. Ammonium bicarbonate is clearly not suitable as a phase-forming salt, because of its too-low solubility in water.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalJournal of Chromatography B: Biomedical Applications
Volume711
Issue number1-2
DOIs
Publication statusPublished - 26 Jun 1998
Externally publishedYes

Keywords

  • Ammonium carbamate
  • Aqueous two-phase systems
  • Volatile salts

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