Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats

Marina Fidelis; Jânio Sousa Santos; Graziela Bragueto Escher; Ramon Silva Rocha; Adriano Gomes Cruz; Thiago Mendanha Cruz; Mariza Boscacci Marques; Juliana Barbosa Nunes; Mariana Araújo Vieira do Carmo; Leonardo Augusto de Almeida; Tai Kaneshima; Luciana Azevedo; Daniel Granato

doi:10.1016/j.foodchem.2020.127565

Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats

Marina Fidelis
, Jânio Sousa Santos
, Graziela Bragueto Escher
, Ramon Silva Rocha
, Adriano Gomes Cruz
, Thiago Mendanha Cruz
, Mariza Boscacci Marques
, Juliana Barbosa Nunes
, Mariana Araújo Vieira do Carmo
, Leonardo Augusto de Almeida
, Tai Kaneshima
, Luciana Azevedo
, Daniel Granato

Research output: Contribution to journal › Article › peer-review

Abstract

The chemical composition, antioxidant activity (AA), cytotoxic activity, antihemolytic effects, and enzyme inhibition (EI) of lyophilized jabuticaba (Myrciaria jaboticaba) seed extract (LJE) was studied. The main compounds found were castalagin, vescalagin, procyanidin A2, and ellagic acid. LJE was more toxic to cancer cells than to normal cells, meaning relative toxicological safety. This cytotoxic effect can be attributed to the pro-oxidant effect observed in the reactive oxygen species (ROS) generation assay. LJE inhibited α-amylase, α-glucosidase, and ACE-I activities and protected human erythrocytes from hemolysis. LJE was incorporated into yogurts at different concentrations and the total phenolic content, AA, and EI increased in a dose-dependent manner. LJE-containing yogurt presented 86% sensory acceptance. The yogurt was administered to Wistar rats bearing cancer and it modulated the gut bacterial microbiota, having a prebiotic effect. LJE is a potential functional ingredient for food companies looking for TPC, AA, and prebiotic effect in vivo.

Original language	English
Article number	127565
Journal	Food Chemistry
Volume	334
DOIs	https://doi.org/10.1016/j.foodchem.2020.127565
Publication status	Published - 1 Jan 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Castalagin
Cytotoxic activity
Dairy products
Fruit seeds
Gut microbiota modulation
Vescalagin

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Fidelis, M., Santos, J. S., Escher, G. B., Rocha, R. S., Cruz, A. G., Cruz, T. M., Marques, M. B., Nunes, J. B., do Carmo, M. A. V., de Almeida, L. A., Kaneshima, T., Azevedo, L., & Granato, D. (2021). Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats. Food Chemistry, 334, Article 127565. https://doi.org/10.1016/j.foodchem.2020.127565

@article{308ea195c8a54a779250df11438fa6bc,

title = "Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats",

abstract = "The chemical composition, antioxidant activity (AA), cytotoxic activity, antihemolytic effects, and enzyme inhibition (EI) of lyophilized jabuticaba (Myrciaria jaboticaba) seed extract (LJE) was studied. The main compounds found were castalagin, vescalagin, procyanidin A2, and ellagic acid. LJE was more toxic to cancer cells than to normal cells, meaning relative toxicological safety. This cytotoxic effect can be attributed to the pro-oxidant effect observed in the reactive oxygen species (ROS) generation assay. LJE inhibited α-amylase, α-glucosidase, and ACE-I activities and protected human erythrocytes from hemolysis. LJE was incorporated into yogurts at different concentrations and the total phenolic content, AA, and EI increased in a dose-dependent manner. LJE-containing yogurt presented 86\% sensory acceptance. The yogurt was administered to Wistar rats bearing cancer and it modulated the gut bacterial microbiota, having a prebiotic effect. LJE is a potential functional ingredient for food companies looking for TPC, AA, and prebiotic effect in vivo.",

keywords = "Castalagin, Cytotoxic activity, Dairy products, Fruit seeds, Gut microbiota modulation, Vescalagin",

author = "Marina Fidelis and Santos, \{J{\^a}nio Sousa\} and Escher, \{Graziela Bragueto\} and Rocha, \{Ramon Silva\} and Cruz, \{Adriano Gomes\} and Cruz, \{Thiago Mendanha\} and Marques, \{Mariza Boscacci\} and Nunes, \{Juliana Barbosa\} and \{do Carmo\}, \{Mariana Ara{\'u}jo Vieira\} and \{de Almeida\}, \{Leonardo Augusto\} and Tai Kaneshima and Luciana Azevedo and Daniel Granato",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/j.foodchem.2020.127565",

language = "English",

volume = "334",

journal = "Food Chemistry",

issn = "0308-8146",

}

Fidelis, M, Santos, JS, Escher, GB, Rocha, RS, Cruz, AG, Cruz, TM, Marques, MB, Nunes, JB, do Carmo, MAV, de Almeida, LA, Kaneshima, T, Azevedo, L & Granato, D 2021, 'Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats', Food Chemistry, vol. 334, 127565. https://doi.org/10.1016/j.foodchem.2020.127565

Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats. / Fidelis, Marina; Santos, Jânio Sousa; Escher, Graziela Bragueto et al.
In: Food Chemistry, Vol. 334, 127565, 01.01.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats

AU - Fidelis, Marina

AU - Santos, Jânio Sousa

AU - Escher, Graziela Bragueto

AU - Rocha, Ramon Silva

AU - Cruz, Adriano Gomes

AU - Cruz, Thiago Mendanha

AU - Marques, Mariza Boscacci

AU - Nunes, Juliana Barbosa

AU - do Carmo, Mariana Araújo Vieira

AU - de Almeida, Leonardo Augusto

AU - Kaneshima, Tai

AU - Azevedo, Luciana

AU - Granato, Daniel

PY - 2021/1/1

Y1 - 2021/1/1

N2 - The chemical composition, antioxidant activity (AA), cytotoxic activity, antihemolytic effects, and enzyme inhibition (EI) of lyophilized jabuticaba (Myrciaria jaboticaba) seed extract (LJE) was studied. The main compounds found were castalagin, vescalagin, procyanidin A2, and ellagic acid. LJE was more toxic to cancer cells than to normal cells, meaning relative toxicological safety. This cytotoxic effect can be attributed to the pro-oxidant effect observed in the reactive oxygen species (ROS) generation assay. LJE inhibited α-amylase, α-glucosidase, and ACE-I activities and protected human erythrocytes from hemolysis. LJE was incorporated into yogurts at different concentrations and the total phenolic content, AA, and EI increased in a dose-dependent manner. LJE-containing yogurt presented 86% sensory acceptance. The yogurt was administered to Wistar rats bearing cancer and it modulated the gut bacterial microbiota, having a prebiotic effect. LJE is a potential functional ingredient for food companies looking for TPC, AA, and prebiotic effect in vivo.

AB - The chemical composition, antioxidant activity (AA), cytotoxic activity, antihemolytic effects, and enzyme inhibition (EI) of lyophilized jabuticaba (Myrciaria jaboticaba) seed extract (LJE) was studied. The main compounds found were castalagin, vescalagin, procyanidin A2, and ellagic acid. LJE was more toxic to cancer cells than to normal cells, meaning relative toxicological safety. This cytotoxic effect can be attributed to the pro-oxidant effect observed in the reactive oxygen species (ROS) generation assay. LJE inhibited α-amylase, α-glucosidase, and ACE-I activities and protected human erythrocytes from hemolysis. LJE was incorporated into yogurts at different concentrations and the total phenolic content, AA, and EI increased in a dose-dependent manner. LJE-containing yogurt presented 86% sensory acceptance. The yogurt was administered to Wistar rats bearing cancer and it modulated the gut bacterial microbiota, having a prebiotic effect. LJE is a potential functional ingredient for food companies looking for TPC, AA, and prebiotic effect in vivo.

KW - Castalagin

KW - Cytotoxic activity

KW - Dairy products

KW - Fruit seeds

KW - Gut microbiota modulation

KW - Vescalagin

UR - https://www.scopus.com/pages/publications/85088376552

U2 - 10.1016/j.foodchem.2020.127565

DO - 10.1016/j.foodchem.2020.127565

M3 - Article

C2 - 32717686

AN - SCOPUS:85088376552

SN - 0308-8146

VL - 334

JO - Food Chemistry

JF - Food Chemistry

M1 - 127565

ER -

Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats

Abstract

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Keywords

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