Potent antiviral effect of silver nanoparticles on SARS-CoV-2

Sundararaj S. Jeremiah; Kei Miyakawa; Takeshi Morita; Yutaro Yamaoka; Akihide Ryo

doi:10.1016/j.bbrc.2020.09.018

Potent antiviral effect of silver nanoparticles on SARS-CoV-2

Sundararaj S. Jeremiah, Kei Miyakawa, Takeshi Morita, Yutaro Yamaoka, Akihide Ryo

Yokohama City University

Research output: Contribution to journal › Article › peer-review

Abstract

The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.

Original language	English
Pages (from-to)	195-200
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	533
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2020.09.018
Publication status	Published - 26 Nov 2020

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title = "Potent antiviral effect of silver nanoparticles on SARS-CoV-2",

abstract = "The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.",

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AU - Jeremiah, Sundararaj S.

AU - Miyakawa, Kei

AU - Morita, Takeshi

AU - Yamaoka, Yutaro

AU - Ryo, Akihide

PY - 2020/11/26

Y1 - 2020/11/26

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AB - The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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Potent antiviral effect of silver nanoparticles on SARS-CoV-2

Abstract

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