TY - JOUR
T1 - Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes
AU - Hoffman, M. Camille
AU - Jeffers, Sarah
AU - Carter, Jena
AU - Duthely, Lunthita
AU - Cotter, Amanda
AU - González-Quintero, Víctor Hugo
PY - 2007/5
Y1 - 2007/5
N2 - Objective: The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design: Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results: Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion: AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women.
AB - Objective: The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design: Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results: Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion: AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women.
KW - advanced maternal age
KW - antepartum fetal surveillance
KW - fetal death
UR - http://www.scopus.com/inward/record.url?scp=34247234524&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2006.10.862
DO - 10.1016/j.ajog.2006.10.862
M3 - Article
C2 - 17466664
AN - SCOPUS:34247234524
SN - 0002-9378
VL - 196
SP - e11-e13
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -