TY - JOUR
T1 - Production and isolation of pharmaceutical drug nanoparticles
AU - Verma, Vivek
AU - Ryan, Kevin M.
AU - Padrela, Luis
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/6/15
Y1 - 2021/6/15
N2 - Nanosizing of pharmaceutical drug particles is one of the most important drug delivery platforms approaches for the commercial development of poorly water-soluble drug molecules. Though nanosizing of drug particles has been proven to greatly enhance drugs dissolution rate and apparent solubility, nanosized materials have presented significant challenges for their formulation as solid dosage forms (e.g. tablets, capsules). This is due to the strong Van der Waals attraction forces between dry nanoparticles leading to aggregation, cohesion, and consequently poor flowability. In this review, the broad area of nanomedicines is overviewed with the primary focus on drug nanocrystals and the top-down and bottom-up methods used in their fabrication. The review also looks at how nanosuspensions of pharmaceutical drugs are generated and stabilised, followed by subsequent strategies for isolation of the nanoparticles. A perspective on the future outlook for drug nanocrystals is also presented.
AB - Nanosizing of pharmaceutical drug particles is one of the most important drug delivery platforms approaches for the commercial development of poorly water-soluble drug molecules. Though nanosizing of drug particles has been proven to greatly enhance drugs dissolution rate and apparent solubility, nanosized materials have presented significant challenges for their formulation as solid dosage forms (e.g. tablets, capsules). This is due to the strong Van der Waals attraction forces between dry nanoparticles leading to aggregation, cohesion, and consequently poor flowability. In this review, the broad area of nanomedicines is overviewed with the primary focus on drug nanocrystals and the top-down and bottom-up methods used in their fabrication. The review also looks at how nanosuspensions of pharmaceutical drugs are generated and stabilised, followed by subsequent strategies for isolation of the nanoparticles. A perspective on the future outlook for drug nanocrystals is also presented.
KW - Active pharmaceutical ingredients
KW - Bioavailability
KW - Bottom-up methods
KW - Nanoparticle isolation
KW - Nanoparticle stabilisation
KW - Nanoparticles
KW - Top-down methods
UR - http://www.scopus.com/inward/record.url?scp=85107049291&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2021.120708
DO - 10.1016/j.ijpharm.2021.120708
M3 - Review article
C2 - 33992712
AN - SCOPUS:85107049291
SN - 0378-5173
VL - 603
SP - 120708
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 120708
ER -