TY - JOUR
T1 - Promotion of Mefenamic Acid Nucleation by a Surfactant Additive, Docusate Sodium
AU - Bodnár, Katalin
AU - Hudson, Sarah P.
AU - Rasmuson, Åke C.
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2019/2/6
Y1 - 2019/2/6
N2 - The influence of docusate sodium (DOSS) on the nucleation of mefenamic acid (MEF) has been studied in different dimethylacetamide (DMA)-water mixtures. A series of induction time experiments were conducted under moderate supersaturations, varying the solvent composition and the concentration of DOSS. In 40% DMA-60% water, the presence of 0.1 and 0.2 mg/mL DOSS increased the nucleation rate. Evaluating the results by the classical nucleation theory reveals that the pre-exponential factor (A) increases by approximately 50% while the interfacial energy is essentially uninfluenced. It is also found that the crystal growth rate becomes higher in the presence of DOSS. It is thus hypothesized that transport and desolvation of MEF molecules are facilitated in the presence of DOSS. With increasing amount of DMA in the binary solvent mixture, the influence of DOSS appears to decrease.
AB - The influence of docusate sodium (DOSS) on the nucleation of mefenamic acid (MEF) has been studied in different dimethylacetamide (DMA)-water mixtures. A series of induction time experiments were conducted under moderate supersaturations, varying the solvent composition and the concentration of DOSS. In 40% DMA-60% water, the presence of 0.1 and 0.2 mg/mL DOSS increased the nucleation rate. Evaluating the results by the classical nucleation theory reveals that the pre-exponential factor (A) increases by approximately 50% while the interfacial energy is essentially uninfluenced. It is also found that the crystal growth rate becomes higher in the presence of DOSS. It is thus hypothesized that transport and desolvation of MEF molecules are facilitated in the presence of DOSS. With increasing amount of DMA in the binary solvent mixture, the influence of DOSS appears to decrease.
UR - http://www.scopus.com/inward/record.url?scp=85060043098&partnerID=8YFLogxK
U2 - 10.1021/acs.cgd.8b00995
DO - 10.1021/acs.cgd.8b00995
M3 - Article
AN - SCOPUS:85060043098
SN - 1528-7483
VL - 19
SP - 591
EP - 603
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 2
ER -