Protective effects of curcumin against ischemia-reperfusion injury in the liver

Kowsar Bavarsad; Maryam Matbou Riahi; Saeideh Saadat; George Barreto; Stephen L. Atkin; Amirhossein Sahebkar

doi:10.1016/j.phrs.2018.12.014

Protective effects of curcumin against ischemia-reperfusion injury in the liver

Kowsar Bavarsad, Maryam Matbou Riahi, Saeideh Saadat, George Barreto, Stephen L. Atkin, Amirhossein Sahebkar

Research output: Contribution to journal › Review article › peer-review

Abstract

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.

Original language	English
Pages (from-to)	53-62
Number of pages	10
Journal	Pharmacological Research
Volume	141
DOIs	https://doi.org/10.1016/j.phrs.2018.12.014
Publication status	Published - Mar 2019
Externally published	Yes

Keywords

Curcumin
Ischemia-reperfusion injury
Liver
Transplantation

Access to Document

10.1016/j.phrs.2018.12.014

Cite this

@article{f8707c3fb87b413c9e1a5702d38a0e38,

title = "Protective effects of curcumin against ischemia-reperfusion injury in the liver",

abstract = "Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.",

keywords = "Curcumin, Ischemia-reperfusion injury, Liver, Transplantation",

author = "Kowsar Bavarsad and Riahi, {Maryam Matbou} and Saeideh Saadat and George Barreto and Atkin, {Stephen L.} and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = mar,

doi = "10.1016/j.phrs.2018.12.014",

language = "English",

volume = "141",

pages = "53--62",

journal = "Pharmacological Research",

issn = "1043-6618",

}

TY - JOUR

T1 - Protective effects of curcumin against ischemia-reperfusion injury in the liver

AU - Bavarsad, Kowsar

AU - Riahi, Maryam Matbou

AU - Saadat, Saeideh

AU - Barreto, George

AU - Atkin, Stephen L.

AU - Sahebkar, Amirhossein

PY - 2019/3

Y1 - 2019/3

N2 - Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.

AB - Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Curcumin is a natural product extracted from Curcuma longa that is known to suppress these pathways and as a result reduces liver ischemia-reperfusion injury. This paper gives an overview of the protective effects of curcumin against I/R injury in the liver and discusses the studies that have linked biological functions of curcumin with liver I/R injury improvement.

KW - Curcumin

KW - Ischemia-reperfusion injury

KW - Liver

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=85060272992&partnerID=8YFLogxK

U2 - 10.1016/j.phrs.2018.12.014

DO - 10.1016/j.phrs.2018.12.014

M3 - Review article

C2 - 30562571

AN - SCOPUS:85060272992

SN - 1043-6618

VL - 141

SP - 53

EP - 62

JO - Pharmacological Research

JF - Pharmacological Research

ER -

Protective effects of curcumin against ischemia-reperfusion injury in the liver

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this