TY - JOUR
T1 - Protective Effects of Plant-Derived Compounds Against Traumatic Brain Injury
AU - Khayatan, Danial
AU - Razavi, Seyed Mehrad
AU - Arab, Zahra Najafi
AU - Khanahmadi, Maryam
AU - Samanian, Amirreza
AU - Momtaz, Saeideh
AU - Sukhorukov, Vasily N.
AU - Jamialahmadi, Tannaz
AU - Abdolghaffari, Amir Hossein
AU - Barreto, George E.
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/10
Y1 - 2024/10
N2 - Inflammation in the nervous system is one of the key features of many neurodegenerative diseases. It is increasingly being identified as a critical pathophysiological primitive mechanism associated with chronic neurodegenerative diseases following traumatic brain injury (TBI). Phytochemicals have a wide range of clinical properties due to their antioxidant and anti-inflammatory effects. Currently, there are few drugs available for the treatment of neurodegenerative diseases other than symptomatic relief. Numerous studies have shown that plant-derived compounds, in particular polyphenols, protect against various neurodegenerative diseases and are safe for consumption. Polyphenols exert protective effects on TBI via restoration of nuclear factor kappa B (NF-κB), toll-like receptor-4 (TLR4), and Nod-like receptor family proteins (NLRPs) pathways. In addition, these phytochemicals and their derivatives upregulate the phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/AKT) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, which have critical functions in modulating TBI symptoms. There is supporting evidence that medicinal plants and phytochemicals are protective in different TBI models, though future clinical trials are needed to clarify the precise mechanisms and functions of different polyphenolic compounds in TBI.
AB - Inflammation in the nervous system is one of the key features of many neurodegenerative diseases. It is increasingly being identified as a critical pathophysiological primitive mechanism associated with chronic neurodegenerative diseases following traumatic brain injury (TBI). Phytochemicals have a wide range of clinical properties due to their antioxidant and anti-inflammatory effects. Currently, there are few drugs available for the treatment of neurodegenerative diseases other than symptomatic relief. Numerous studies have shown that plant-derived compounds, in particular polyphenols, protect against various neurodegenerative diseases and are safe for consumption. Polyphenols exert protective effects on TBI via restoration of nuclear factor kappa B (NF-κB), toll-like receptor-4 (TLR4), and Nod-like receptor family proteins (NLRPs) pathways. In addition, these phytochemicals and their derivatives upregulate the phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/AKT) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways, which have critical functions in modulating TBI symptoms. There is supporting evidence that medicinal plants and phytochemicals are protective in different TBI models, though future clinical trials are needed to clarify the precise mechanisms and functions of different polyphenolic compounds in TBI.
KW - Neurodegenerative diseases
KW - Neuroinflammation
KW - Oxidative stress
KW - Polyphenol
KW - Traumatic brain injury (TBI)
UR - http://www.scopus.com/inward/record.url?scp=85186399351&partnerID=8YFLogxK
U2 - 10.1007/s12035-024-04030-w
DO - 10.1007/s12035-024-04030-w
M3 - Review article
C2 - 38427213
AN - SCOPUS:85186399351
SN - 0893-7648
VL - 61
SP - 7732
EP - 7750
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 10
ER -