TY - JOUR
T1 - RACK1, A multifaceted scaffolding protein
T2 - Structure and function
AU - Adams, David R.
AU - Ron, Dorit
AU - Kiely, Patrick A.
PY - 2011
Y1 - 2011
N2 - The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). RACK1 adopts a seven-bladed β-propeller structure which facilitates protein binding. RACK1 has a significant role to play in shuttling proteins around the cell, anchoring proteins at particular locations and in stabilising protein activity. It interacts with the ribosomal machinery, with several cell surface receptors and with proteins in the nucleus. As a result, RACK1 is a key mediator of various pathways and contributes to numerous aspects of cellular function. Here, we discuss RACK1 gene and structure and its role in specific signaling pathways, and address how posttranslational modifications facilitate subcellular location and translocation of RACK1. This review condenses several recent studies suggesting a role for RACK1 in physiological processes such as development, cell migration, central nervous system (CN) function and circadian rhythm as well as reviewing the role of RACK1 in disease.
AB - The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). RACK1 adopts a seven-bladed β-propeller structure which facilitates protein binding. RACK1 has a significant role to play in shuttling proteins around the cell, anchoring proteins at particular locations and in stabilising protein activity. It interacts with the ribosomal machinery, with several cell surface receptors and with proteins in the nucleus. As a result, RACK1 is a key mediator of various pathways and contributes to numerous aspects of cellular function. Here, we discuss RACK1 gene and structure and its role in specific signaling pathways, and address how posttranslational modifications facilitate subcellular location and translocation of RACK1. This review condenses several recent studies suggesting a role for RACK1 in physiological processes such as development, cell migration, central nervous system (CN) function and circadian rhythm as well as reviewing the role of RACK1 in disease.
KW - (Gβ)
KW - PKCβII
KW - RACK1
KW - WD-repeat
KW - guanine nucleotide binding protein 2-like 1
KW - heterotrimeric G-proteins
KW - scaffolding protein
UR - http://www.scopus.com/inward/record.url?scp=80053537984&partnerID=8YFLogxK
U2 - 10.1186/1478-811X-9-22
DO - 10.1186/1478-811X-9-22
M3 - Review article
AN - SCOPUS:80053537984
SN - 1478-811X
VL - 9
SP - 22
JO - Cell Communication and Signaling
JF - Cell Communication and Signaling
M1 - 22
ER -