TY - JOUR
T1 - RACK(1) to the future - A historical perspective
AU - Ron, Dorit
AU - Adams, David R.
AU - Baillie, George S.
AU - Long, Aideen
AU - O'Connor, Rosemary
AU - Kiely, Patrick A.
PY - 2013
Y1 - 2013
N2 - This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1's role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.
AB - This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1's role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.
UR - http://www.scopus.com/inward/record.url?scp=84880912009&partnerID=8YFLogxK
U2 - 10.1186/1478-811X-11-53
DO - 10.1186/1478-811X-11-53
M3 - Review article
C2 - 23915285
AN - SCOPUS:84880912009
SN - 1478-811X
VL - 11
SP - 53
JO - Cell Communication and Signaling
JF - Cell Communication and Signaling
IS - 1
M1 - 53
ER -